Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolo...

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Vydáno v:	Cell Ročník 174; číslo 6; s. 1571
Hlavní autoři:	Dyar, Kenneth A, Lutter, Dominik, Artati, Anna, Ceglia, Nicholas J, Liu, Yu, Armenta, Danny, Jastroch, Martin, Schneider, Sandra, de Mateo, Sara, Cervantes, Marlene, Abbondante, Serena, Tognini, Paola, Orozco-Solis, Ricardo, Kinouchi, Kenichiro, Wang, Christina, Swerdloff, Ronald, Nadeef, Seba, Masri, Selma, Magistretti, Pierre, Orlando, Valerio, Borrelli, Emiliana, Uhlenhaut, N Henriette, Baldi, Pierre, Adamski, Jerzy, Tschöp, Matthias H, Eckel-Mahan, Kristin, Sassone-Corsi, Paolo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.09.2018
Témata:	Animals Circadian Clocks - physiology Diet, High-Fat Energy Metabolism Liver - metabolism Male Metabolic Networks and Pathways Metabolome Metabolomics Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism Prefrontal Cortex - metabolism Suprachiasmatic Nucleus - metabolism Uncoupling Protein 1 - metabolism metabolism clock circadian rhythms metabolomics CircadiOmics high-fat diet
ISSN:	1097-4172, 1097-4172
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