Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolo...

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Published in:Cell Vol. 174; no. 6; p. 1571
Main Authors: Dyar, Kenneth A, Lutter, Dominik, Artati, Anna, Ceglia, Nicholas J, Liu, Yu, Armenta, Danny, Jastroch, Martin, Schneider, Sandra, de Mateo, Sara, Cervantes, Marlene, Abbondante, Serena, Tognini, Paola, Orozco-Solis, Ricardo, Kinouchi, Kenichiro, Wang, Christina, Swerdloff, Ronald, Nadeef, Seba, Masri, Selma, Magistretti, Pierre, Orlando, Valerio, Borrelli, Emiliana, Uhlenhaut, N Henriette, Baldi, Pierre, Adamski, Jerzy, Tschöp, Matthias H, Eckel-Mahan, Kristin, Sassone-Corsi, Paolo
Format: Journal Article
Language:English
Published: United States 06.09.2018
Subjects:
Animals
Circadian Clocks - physiology
Diet, High-Fat
Energy Metabolism
Liver - metabolism
Male
Metabolic Networks and Pathways
Metabolome
Metabolomics
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
Prefrontal Cortex - metabolism
Suprachiasmatic Nucleus - metabolism
Uncoupling Protein 1 - metabolism
metabolism
clock
circadian rhythms
metabolomics
CircadiOmics
high-fat diet
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve our understanding of health and disease.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2018.08.042