Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain...

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Veröffentlicht in:	Cell Jg. 166; H. 2; S. 394
Hauptverfasser:	Baldridge, Ryan D, Rapoport, Tom A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.07.2016
Schlagworte:	Adenosine Triphosphatases - metabolism Cell Cycle Proteins - metabolism Endoplasmic Reticulum - metabolism Endoplasmic Reticulum-Associated Degradation Protein Folding Proteolipids - chemistry Proteolipids - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination Valosin Containing Protein
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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