Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous...

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Bibliographic Details
Published in:	Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 12; pp. 1035 - 1049
Main Authors:	Raffaello, Anna, Mammucari, Cristina, Gherardi, Gaia, Rizzuto, Rosario
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2016
Subjects:	Animals calcium Calcium - metabolism calcium channels Calcium Channels - genetics Calcium Channels - metabolism calcium signaling Calcium Signaling - physiology cryo-electron microscopy endoplasmic reticulum Endoplasmic Reticulum - metabolism Gene Expression Regulation - physiology Homeostasis Humans lysosomes Lysosomes - metabolism mitochondria Mitochondria - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Muscle, Striated - metabolism Muscle, Striated - ultrastructure ORAI1 Protein - genetics ORAI1 Protein - metabolism pathophysiology Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism Type C Phospholipases - genetics Type C Phospholipases - metabolism
ISSN:	0968-0004, 1362-4326
Online Access:	Get full text
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