Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous...

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Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 12; pp. 1035 - 1049
Main Authors: Raffaello, Anna, Mammucari, Cristina, Gherardi, Gaia, Rizzuto, Rosario
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.12.2016
Subjects:
Animals
calcium
Calcium - metabolism
calcium channels
Calcium Channels - genetics
Calcium Channels - metabolism
calcium signaling
Calcium Signaling - physiology
cryo-electron microscopy
endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Gene Expression Regulation - physiology
Homeostasis
Humans
lysosomes
Lysosomes - metabolism
mitochondria
Mitochondria - metabolism
Muscle, Skeletal - metabolism
Muscle, Skeletal - ultrastructure
Muscle, Striated - metabolism
Muscle, Striated - ultrastructure
ORAI1 Protein - genetics
ORAI1 Protein - metabolism
pathophysiology
Ryanodine Receptor Calcium Release Channel - genetics
Ryanodine Receptor Calcium Release Channel - metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
Stromal Interaction Molecule 1 - genetics
Stromal Interaction Molecule 1 - metabolism
Type C Phospholipases - genetics
Type C Phospholipases - metabolism
ISSN:0968-0004, 1362-4326
Online Access:Get full text
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Summary:In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology. Ca2+ signaling is regulated by the intimate interconnection between intracellular organelles and plasma membrane channels. The ultrastructures of endoplasmic reticulum and mitochondrial Ca2+ channels have been determined. Great advances have been made in our understanding of the function and regulation of the mitochondrial calcium uniporter. Studies on endolysosomal Ca2+ signaling unravel a potential contribution of this compartment to global Ca2+ homeostasis.
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ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2016.09.001