Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes
In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous...
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| Published in: | Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 41; no. 12; pp. 1035 - 1049 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01.12.2016
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| Subjects: | |
| ISSN: | 0968-0004, 1362-4326 |
| Online Access: | Get full text |
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| Abstract | In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology.
Ca2+ signaling is regulated by the intimate interconnection between intracellular organelles and plasma membrane channels.
The ultrastructures of endoplasmic reticulum and mitochondrial Ca2+ channels have been determined.
Great advances have been made in our understanding of the function and regulation of the mitochondrial calcium uniporter.
Studies on endolysosomal Ca2+ signaling unravel a potential contribution of this compartment to global Ca2+ homeostasis. |
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| AbstractList | In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology.In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology. In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles, which have important implications for whole cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), the continuous update on the structure, regulation and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this Review, we summarize recent discoveries on the regulation of inter-organellar Ca2+ homeostasis and its role in pathophysiology. In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology. Ca2+ signaling is regulated by the intimate interconnection between intracellular organelles and plasma membrane channels. The ultrastructures of endoplasmic reticulum and mitochondrial Ca2+ channels have been determined. Great advances have been made in our understanding of the function and regulation of the mitochondrial calcium uniporter. Studies on endolysosomal Ca2+ signaling unravel a potential contribution of this compartment to global Ca2+ homeostasis. In recent years, rapid discoveries have been made relating to Ca handling at specific organelles that have important implications for whole-cell Ca homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca homeostasis and its role in pathophysiology. In recent years, rapid discoveries have been made relating to Ca²⁺ handling at specific organelles that have important implications for whole-cell Ca²⁺ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca²⁺ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca²⁺ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca²⁺ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca²⁺ homeostasis and its role in pathophysiology. |
| Author | Raffaello, Anna Rizzuto, Rosario Mammucari, Cristina Gherardi, Gaia |
| AuthorAffiliation | 1 Department of Biomedical Sciences, University of Padua, 35131, Italy 2 Neuroscience Institute, National Research Council, Padua, 35131, Italy |
| AuthorAffiliation_xml | – name: 2 Neuroscience Institute, National Research Council, Padua, 35131, Italy – name: 1 Department of Biomedical Sciences, University of Padua, 35131, Italy |
| Author_xml | – sequence: 1 givenname: Anna surname: Raffaello fullname: Raffaello, Anna email: anna.raffaello@unipd.it organization: Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy – sequence: 2 givenname: Cristina surname: Mammucari fullname: Mammucari, Cristina email: cristina.mammucari@unipd.it organization: Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy – sequence: 3 givenname: Gaia surname: Gherardi fullname: Gherardi, Gaia organization: Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy – sequence: 4 givenname: Rosario surname: Rizzuto fullname: Rizzuto, Rosario email: rosario.rizzuto@unipd.it organization: Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27692849$$D View this record in MEDLINE/PubMed |
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| Snippet | In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+... In recent years, rapid discoveries have been made relating to Ca handling at specific organelles that have important implications for whole-cell Ca... In recent years, rapid discoveries have been made relating to Ca²⁺ handling at specific organelles that have important implications for whole-cell Ca²⁺... In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles, which have important implications for whole cell Ca2+... |
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| SubjectTerms | Animals calcium Calcium - metabolism calcium channels Calcium Channels - genetics Calcium Channels - metabolism calcium signaling Calcium Signaling - physiology cryo-electron microscopy endoplasmic reticulum Endoplasmic Reticulum - metabolism Gene Expression Regulation - physiology Homeostasis Humans lysosomes Lysosomes - metabolism mitochondria Mitochondria - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Muscle, Striated - metabolism Muscle, Striated - ultrastructure ORAI1 Protein - genetics ORAI1 Protein - metabolism pathophysiology Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism Type C Phospholipases - genetics Type C Phospholipases - metabolism |
| Title | Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes |
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