S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood

RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 43; p. 17058
Main Authors:	Reynolds, James D, Ahearn, Gregory S, Angelo, Michael, Zhang, Jian, Cobb, Fred, Stamler, Jonathan S
Format:	Journal Article
Language:	English
Published:	United States 23.10.2007
Subjects:	Blood Blood Banks Cell Hypoxia Erythrocytes - cytology Erythrocytes - metabolism Hemoglobins - deficiency Humans Nitric Oxide - metabolism Nitrosation S-Nitrosothiols - metabolism Time Factors Vasodilation
ISSN:	0027-8424
Online Access:	Get more information
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