Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. Administration of Gal3 to mice causes insulin r...

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Bibliographic Details
Published in:	Cell Vol. 167; no. 4; p. 973
Main Authors:	Li, Pingping, Liu, Shuainan, Lu, Min, Bandyopadhyay, Gautum, Oh, Dayoung, Imamura, Takeshi, Johnson, Andrew M F, Sears, Dorothy, Shen, Zhufang, Cui, Bing, Kong, Lijuan, Hou, Shaocong, Liang, Xiao, Iovino, Salvatore, Watkins, Steven M, Ying, Wei, Osborn, Olivia, Wollam, Joshua, Brenner, Martin, Olefsky, Jerrold M
Format:	Journal Article
Language:	English
Published:	United States 03.11.2016
Subjects:	Adipocytes - metabolism Adipocytes - pathology Animals Chemotaxis Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Galectin 3 - antagonists & inhibitors Galectin 3 - blood Galectin 3 - genetics Galectin 3 - metabolism Hepatocytes - metabolism Hepatocytes - pathology Humans Insulin - blood Insulin Resistance Macrophages - immunology Macrophages - pathology Mice Mice, Knockout Muscle Cells - metabolism Muscle Cells - pathology Obesity - immunology Obesity - metabolism Obesity - pathology inflammation galectin-3 insulin resistance
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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