Mechanisms of pathological scarring: Role of myofibroblasts and current developments

ABSTRACT Myofibroblasts play a key role in the wound‐healing process, promoting wound closure and matrix deposition. These cells normally disappear from granulation tissue by apoptosis after wound closure, but under some circumstances, they persist and may contribute to pathological scar formation....

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Bibliographic Details

Published in:	Wound repair and regeneration Vol. 19; no. s1; pp. s10 - s15
Main Authors:	Sarrazy, Vincent, Billet, Fabrice, Micallef, Ludovic, Coulomb, Bernard, Desmoulière, Alexis
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01.09.2011
Subjects:	Cicatrix - physiopathology Cicatrix, Hypertrophic - physiopathology Granulation Tissue - physiology Humans Keloid - physiopathology Liver - physiopathology Myofibroblasts - cytology Myofibroblasts - physiology Neoplasms - physiopathology Stress, Mechanical Transforming Growth Factor beta1 - physiology Wound Healing - physiology
ISSN:	1067-1927, 1524-475X, 1524-475X
Online Access:	Get full text
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