Social relationships, amyloid burden, and dementia: The ARIC‐PET study
INTRODUCTION This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden. METHODS Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measur...
Gespeichert in:
| Veröffentlicht in: | Alzheimer's & dementia : diagnosis, assessment & disease monitoring Jg. 16; H. 2; S. e12560 - n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
John Wiley and Sons Inc
01.04.2024
Wiley |
| Schlagworte: | |
| ISSN: | 2352-8729, 2352-8729 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | INTRODUCTION
This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden.
METHODS
Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measure, “social relationships,” was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012–2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid‐life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.
RESULTS
Among 310 participants without dementia, strong mid‐life social relationships were associated independently with lower dementia risk. Elevated late‐life brain amyloid was associated with greater dementia risk.
DISCUSSION
Although mid‐life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia. |
|---|---|
| AbstractList | INTRODUCTION
This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden.
METHODS
Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measure, “social relationships,” was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012–2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid‐life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.
RESULTS
Among 310 participants without dementia, strong mid‐life social relationships were associated independently with lower dementia risk. Elevated late‐life brain amyloid was associated with greater dementia risk.
DISCUSSION
Although mid‐life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia. This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.INTRODUCTIONThis study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.METHODSParticipants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.Among 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk.RESULTSAmong 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk.Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.DISCUSSIONAlthough mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia. Abstract INTRODUCTION This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden. METHODS Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measure, “social relationships,” was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012–2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid‐life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models. RESULTS Among 310 participants without dementia, strong mid‐life social relationships were associated independently with lower dementia risk. Elevated late‐life brain amyloid was associated with greater dementia risk. DISCUSSION Although mid‐life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia. This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden. Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models. Among 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk. Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia. |
| Author | Groechel, Renée C. Gottesman, Rebecca F. Wong, Dean F. Liu, Chelsea Lutsey, Pamela L. Mosley, Thomas H. Sharrett, A. Richey Kucharska‐Newton, Anna M. Liu, Albert C. Palta, Priya Knopman, David S. Walker, Keenan A. Koton, Silvia |
| AuthorAffiliation | 1 National Institute of Neurological Disorders & Stroke Intramural Research Program National Institutes of Health Bethesda Maryland USA 4 Department of Neurology Mayo Clinic Rochester Minnesota USA 6 Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA 3 Department of Epidemiology George Washington University‐Milken Institute School of Public Health Washington District of Columbia USA 8 Department of Medicine University of Mississippi Medical Center Jackson Mississippi USA 9 Department of Neurology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA 10 National Institute on Aging Intramural Research Program National Institutes of Health Bethesda Maryland USA 7 Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA 2 Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA 11 Mallinckr |
| AuthorAffiliation_xml | – name: 2 Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA – name: 8 Department of Medicine University of Mississippi Medical Center Jackson Mississippi USA – name: 10 National Institute on Aging Intramural Research Program National Institutes of Health Bethesda Maryland USA – name: 9 Department of Neurology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – name: 1 National Institute of Neurological Disorders & Stroke Intramural Research Program National Institutes of Health Bethesda Maryland USA – name: 4 Department of Neurology Mayo Clinic Rochester Minnesota USA – name: 11 Mallinckrodt Institute of Radiology Washington University St. Louis Missouri USA – name: 5 Department of Nursing The Stanley Steyer School of Health Professions Tel Aviv University Tel Aviv Israel – name: 7 Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Minnesota USA – name: 3 Department of Epidemiology George Washington University‐Milken Institute School of Public Health Washington District of Columbia USA – name: 6 Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA |
| Author_xml | – sequence: 1 givenname: Renée C. orcidid: 0000-0002-1771-5171 surname: Groechel fullname: Groechel, Renée C. organization: National Institutes of Health – sequence: 2 givenname: Albert C. surname: Liu fullname: Liu, Albert C. organization: University of North Carolina Gillings School of Global Public Health – sequence: 3 givenname: Chelsea surname: Liu fullname: Liu, Chelsea organization: George Washington University‐Milken Institute School of Public Health – sequence: 4 givenname: David S. surname: Knopman fullname: Knopman, David S. organization: Mayo Clinic – sequence: 5 givenname: Silvia surname: Koton fullname: Koton, Silvia organization: Johns Hopkins University Bloomberg School of Public Health – sequence: 6 givenname: Anna M. surname: Kucharska‐Newton fullname: Kucharska‐Newton, Anna M. organization: University of North Carolina Gillings School of Global Public Health – sequence: 7 givenname: Pamela L. surname: Lutsey fullname: Lutsey, Pamela L. organization: University of Minnesota School of Public Health – sequence: 8 givenname: Thomas H. surname: Mosley fullname: Mosley, Thomas H. organization: University of Mississippi Medical Center – sequence: 9 givenname: Priya surname: Palta fullname: Palta, Priya organization: University of North Carolina at Chapel Hill – sequence: 10 givenname: A. Richey surname: Sharrett fullname: Sharrett, A. Richey organization: Johns Hopkins University Bloomberg School of Public Health – sequence: 11 givenname: Keenan A. surname: Walker fullname: Walker, Keenan A. organization: National Institutes of Health – sequence: 12 givenname: Dean F. surname: Wong fullname: Wong, Dean F. organization: Washington University – sequence: 13 givenname: Rebecca F. surname: Gottesman fullname: Gottesman, Rebecca F. email: rebecca.gottesman@nih.gov organization: National Institutes of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38571965$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1DAUhS1URH_ohgdAWSLUKf6PwwaNpoWOVAkEw9ryz03HlRNP4wQ0Ox6BZ-RJSCctahFiZfv6nO_o6hyivTa1gNALgk8JxvSNN56eEiokfoIOKBN0pkpa7T2476PjnK8xxoRXlBP8DO0zJUpSSXGALr4kF0wsOoimD6nN67DJJ4VptjEFX9ih89CO79YXHhpo-2DeFqs1FPPPy8WvHz8_na-K3A9--xw9rU3McHx3HqGv789Xi4vZ5ccPy8X8cuaE4HgGShlVEsGYt5IaQrBQJXdYUsuoBOsMEMu48KzmjhmQNYjSGEGghHFJwo7QcuL6ZK71pguN6bY6maB3g9RdadP1wUXQnIA0xNZOGuAV95WEuraUWlsqblU5st5NrM1gG_BuXK8z8RH08U8b1voqfdMEV0oRIkfCqztCl24GyL1uQnYQo2khDVkzzBjGCpdqlL58GPYn5b6LUYAngetSzh3U2oV-V8qYHeIYqm8b17eN613jo-X1X5Z76j_FZBJ_DxG2_1Hqs_kZnTy_AatLulU |
| CitedBy_id | crossref_primary_10_2174_0115672050373522250421054927 crossref_primary_10_1161_STROKEAHA_124_049147 crossref_primary_10_1161_STROKEAHA_124_047455 crossref_primary_10_1007_s15005_024_3978_8 crossref_primary_10_1002_alz_70365 |
| Cites_doi | 10.3233/JAD-231218 10.1212/WNL.0000000000011375 10.1016/j.annemergmed.2010.06.560 10.1212/01.wnl.0000172958.95282.2a 10.1016/0167-5273(87)90029-5 10.1089/rej.2010.1103 10.1002/alz.12362 10.1093/ajcn/36.5.936 10.1038/s43587-023-00387-0 10.1212/WNL.0000000000002914 10.1016/S1474-4422(20)30039-9 10.1177/2158244012461923 10.1016/j.jacc.2021.04.035 10.1016/j.neurobiolaging.2018.06.012 10.1016/j.jagp.2019.05.005 10.1016/j.amjcard.2010.01.340 10.1007/s11682-016-9581-y 10.1001/jamaneurol.2017.0244 10.1016/j.neurobiolaging.2017.06.016 10.1016/j.atherosclerosis.2021.04.020 10.1016/j.arr.2023.101986 10.1016/j.dadm.2015.12.002 10.3233/JAD‐201426 10.1016/j.tics.2011.09.004 10.1093/geront/46.4.503 10.1093/ageing/afw060 10.1002/alz.13016 10.1161/STROKEAHA.114.005815 10.1093/ije/24.4.685 10.1001/jamapsychiatry.2016.2657 10.1097/YCO.0000000000000779 10.1161/STROKEAHA.114.007847 10.1111/j.1559-1816.1983.tb02325.x 10.1146/annurev-psych-122216-011902 10.1097/00003727-198811000-00008 10.1016/j.jalz.2010.03.004 10.1002/ana.25380 10.1002/gps.5601 10.1002/ana.26447 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. |
| Copyright_xml | – notice: 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. |
| DBID | 24P AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1002/dad2.12560 |
| DatabaseName | Wiley-Blackwell Open Access Titles CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | GROECHEL et al |
| EISSN | 2352-8729 |
| EndPage | n/a |
| ExternalDocumentID | oai_doaj_org_article_41e6a1bfc6ae494d96effb22bb784b87 PMC10988116 38571965 10_1002_dad2_12560 DAD212560 |
| Genre | article Journal Article |
| GrantInformation_xml | – fundername: ARIC‐PET Study funderid: R01AG040282 – fundername: National Heart, Lung, and Blood Institute funderid: 75N92022D00001; 75N92022D00002; 75N92022D00003; 75N92022D00004; 75N92022D00005 – fundername: ARIC Neurocognitive Study funderid: U01HL096812; U01HL096814; U01HL096899; U01HL096902; U01HL096917 – fundername: NHLBI NIH HHS grantid: U01 HL096814 – fundername: NHLBI NIH HHS grantid: U01 HL096899 – fundername: NHLBI NIH HHS grantid: U01 HL096917 – fundername: NHLBI NIH HHS grantid: U01 HL096812 – fundername: NHLBI NIH HHS grantid: 75N92022D00002 – fundername: NHLBI NIH HHS grantid: 75N92022D00001 – fundername: NIA NIH HHS grantid: R01 AG040282 – fundername: NHLBI NIH HHS grantid: 75N92022D00004 – fundername: NHLBI NIH HHS grantid: U01 HL096902 – fundername: NHLBI NIH HHS grantid: 75N92022D00003 – fundername: ARIC‐PET Study grantid: R01AG040282 – fundername: ARIC Neurocognitive Study grantid: U01HL096812; U01HL096814; U01HL096899; U01HL096902; U01HL096917 |
| GroupedDBID | 0R~ 0SF 1OC 24P 457 53G 6I. 7RV 7X7 8FI 8FJ AACTN AAEDW AAFTH AAHHS AALRI AAXUO ABMAC ABUWG ACCFJ ACCMX ACGFS ACXQS ADBBV ADEZE ADKYN ADPDF ADRAZ ADVLN ADZMN ADZOD AEEZP AEQDE AEVXI AEXQZ AFKRA AFTJW AGHFR AITUG AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AMRAJ AOIJS AVUZU BAWUL BENPR CCPQU EBS EJD EMOBN FDB FYUFA GROUPED_DOAJ HMCUK HYE IAO IHR INH ITC KQ8 M48 M~E NAPCQ NCXOZ O9- OK1 OVD OVEED PIMPY ROL RPM SSZ TEORI UKHRP WIN AAYWO AAYXX AFFHD CITATION PHGZM PHGZT PPXIY NPM 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c5540-e88a871533db62a1105874c062b326ebcae1b345d3f4c3ae6fe57aa51e7e25613 |
| IEDL.DBID | 24P |
| ISICitedReferencesCount | 3 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001195607800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2352-8729 |
| IngestDate | Mon Nov 10 04:32:47 EST 2025 Tue Nov 04 02:05:51 EST 2025 Thu Sep 04 18:39:00 EDT 2025 Thu Apr 03 07:04:27 EDT 2025 Tue Nov 18 22:27:29 EST 2025 Sat Nov 29 07:12:54 EST 2025 Wed Jan 22 17:18:38 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | dementia mid‐life social relationships positron emission tomography Atherosclerosis Risk in Communities study amyloid beta |
| Language | English |
| License | Attribution-NonCommercial 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5540-e88a871533db62a1105874c062b326ebcae1b345d3f4c3ae6fe57aa51e7e25613 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-1771-5171 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdad2.12560 |
| PMID | 38571965 |
| PQID | 3033008078 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_41e6a1bfc6ae494d96effb22bb784b87 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10988116 proquest_miscellaneous_3033008078 pubmed_primary_38571965 crossref_citationtrail_10_1002_dad2_12560 crossref_primary_10_1002_dad2_12560 wiley_primary_10_1002_dad2_12560_DAD212560 |
| PublicationCentury | 2000 |
| PublicationDate | April‐June 2024 |
| PublicationDateYYYYMMDD | 2024-04-01 |
| PublicationDate_xml | – month: 04 year: 2024 text: April‐June 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Alzheimer's & dementia : diagnosis, assessment & disease monitoring |
| PublicationTitleAlternate | Alzheimers Dement (Amst) |
| PublicationYear | 2024 |
| Publisher | John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley and Sons Inc – name: Wiley |
| References | 2021; 329 1982; 36 2022; 92 2010; 105 2023; 19 1988; 11 2016; 73 2024; 97 2005; 65 2011; 57 2011; 15 2011; 14 2023; 3 2021; 96 1983; 13 2014; 45 1987; 17 2020; 19 2018; 69 2015; 46 2021; 36 2017; 74 2012; 2 2016; 2 2023; 89 2021; 77 2017; 59 2019; 85 2006; 46 2021 2017; 11 1995; 24 2021; 17 2018; 70 2016; 87 2022; 35 2019; 27 2010; 6 2016; 45 2021; 81 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_41_1 e_1_2_8_40_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 Sakr‐Ashour F (e_1_2_8_26_1) 2021 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 46 start-page: 503 issue: 4 year: 2006 end-page: 513 article-title: Performance of an abbreviated version of the Lubben Social Network Scale among three European community‐dwelling older adult populations publication-title: Gerontologist – volume: 77 start-page: 2939 issue: 23 year: 2021 end-page: 2959 article-title: The ARIC (Atherosclerosis Risk in Communities) Study: JACC focus seminar 3/8 publication-title: J Am Coll Cardiol – volume: 87 start-page: 473 issue: 5 year: 2016 end-page: 480 article-title: The ARIC‐PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE publication-title: Neurology – volume: 24 start-page: 685 year: 1995 end-page: 693 article-title: Ability of the Atherosclerosis Risk in Communities (ARIC)/Baecke questionnaire to assess leisure–time physical activity publication-title: Int J Epidemiol – volume: 45 start-page: 475 issue: 4 year: 2016 end-page: 480 article-title: Social support and cognition in a community‐based cohort: the Atherosclerosis Risk in Communities (ARIC) study publication-title: Age Ageing – volume: 329 start-page: 36 year: 2021 end-page: 43 article-title: Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: the Atherosclerosis Risk in Communities (ARIC) Study publication-title: Atherosclerosis – volume: 17 start-page: 15 issue: 1 year: 1987 end-page: 24 article-title: A questionnaire to assess premonitory symptoms of myocardial infarction publication-title: Int J Cardiol – volume: 15 start-page: 520 issue: 11 year: 2011 end-page: 526 article-title: Lifespan brain activity, β‐amyloid, and Alzheimer's disease publication-title: Trends Cogn Sci – volume: 14 start-page: 143 issue: 2 year: 2011 end-page: 151 article-title: Neuroanatomical correlates of cognitive reserve in Alzheimer disease publication-title: Rejuvenation Res – volume: 65 start-page: 559 issue: 4 year: 2005 end-page: 564 article-title: The AD8: a brief informant interview to detect dementia publication-title: Neurology – year: 2021 – volume: 57 start-page: 653 issue: 6 year: 2011 end-page: 661 article-title: The Six‐Item Screener and AD8 for the detection of cognitive impairment in geriatric emergency department patients publication-title: Ann Emerg Med – volume: 85 start-page: 114 issue: 1 year: 2019 end-page: 124 article-title: Attributable risk of Alzheimer's dementia attributed to age‐related neuropathologies publication-title: Ann Neurol – volume: 6 start-page: 212 issue: 3 year: 2010 end-page: 220 article-title: Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative publication-title: Alzheimer Dement – volume: 27 start-page: 1247 issue: 11 year: 2019 end-page: 1256 article-title: Social relationships and amyloid‐β‐related cognitive decline in cognitively normal older adults publication-title: Am J Geriatr Psychiatry – volume: 81 start-page: 263 issue: 1 year: 2021 end-page: 272 article-title: Social networks and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: the CABLE study publication-title: J Alzheimers Dis – volume: 105 start-page: 1661 issue: 12 year: 2010 end-page: 1665 article-title: Vital exhaustion as a risk factor for adverse cardiac events (from the Atherosclerosis Risk in Communities [ARIC] study) publication-title: Am J Cardiol – volume: 17 start-page: 1966 issue: 12 year: 2021 end-page: 1975 article-title: Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020‐2060) publication-title: Alzheimers Dement – volume: 19 start-page: 1598 issue: 4 year: 2023 end-page: 1695 article-title: 2023 Alzheimer's disease facts and figures publication-title: Alzheimers Dement – volume: 69 start-page: 437 year: 2018 end-page: 458 article-title: Why social relationships are important for physical health: a systems approach to understanding and modifying risk and protection publication-title: Annu Rev Psychol – volume: 2 issue: 3 year: 2012 article-title: Psychometric evaluation of the interpersonal support evaluation list–short form in the ARIC Study Cohort publication-title: SAGE Open – volume: 97 start-page: 1901 issue: 4 year: 2024 end-page: 1911 article-title: Associations between mid‐life psychosocial measures and estimated late life amyloid burden: the Atherosclerosis Risk in Communities (ARIC)‐PET Study publication-title: J Alzheimers Dis – volume: 89 year: 2023 article-title: Associations between social health factors, cognitive activity and neurostructural markers for brain health–a systematic literature review and meta‐analysis publication-title: Ageing Res Rev – volume: 19 start-page: 533 issue: 6 year: 2020 end-page: 543 article-title: Ageing without dementia: can stimulating psychosocial and lifestyle experiences make a difference? publication-title: Lancet Neurol – volume: 70 start-page: 180 year: 2018 end-page: 183 article-title: Lifestyle activities in mid‐life contribute to cognitive reserve in late‐life, independent of education, occupation, and late‐life activities publication-title: Neurobiol Aging – volume: 96 start-page: e964 issue: 7 year: 2021 end-page: e974 article-title: Prospective analysis of leisure‐time physical activity in midlife and beyond and brain damage on MRI in older adults publication-title: Neurology – volume: 11 start-page: 42 issue: 3 year: 1988 end-page: 52 article-title: Assessing social networks among elderly populations publication-title: Fam Community Health – volume: 2 start-page: 1 year: 2016 end-page: 11 article-title: Mild cognitive impairment and dementia prevalence: the Atherosclerosis Risk in Communities neurocognitive study publication-title: Alzheimer's Dement Diagnosis Assess Dis Monit – volume: 59 start-page: 72 year: 2017 end-page: 79 article-title: Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation publication-title: Neurol Aging – volume: 35 start-page: 111 issue: 2 year: 2022 end-page: 117 article-title: Social health, social reserve and dementia publication-title: Curr Opin Psychiatry – volume: 13 start-page: 99 issue: 2 year: 1983 end-page: 125 article-title: Positive events and social supports as buffers of life change stress publication-title: J Appl Soc Psychol – volume: 74 start-page: 718 issue: 6 year: 2017 article-title: Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals publication-title: JAMA Neurol – volume: 46 start-page: 433 issue: 2 year: 2015 end-page: 440 article-title: Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: Atherosclerosis Risk in Communities‐neurocognitive Study publication-title: Stroke – volume: 45 start-page: 2868 issue: 10 year: 2014 end-page: 2873 article-title: Social network, social support, and risk of incident stroke publication-title: Stroke – volume: 3 start-page: 532 issue: 5 year: 2023 end-page: 545 article-title: Social participation and risk of developing dementia publication-title: Nature Aging – volume: 36 start-page: 936 year: 1982 end-page: 942 article-title: A short questionnaire for the measurement of habitual physical activity in epidemiological studies publication-title: Am J Clin Nutr – volume: 92 start-page: 607 year: 2022 end-page: 619 article-title: Associations of vascular risk and amyloid burden with subsequent dementia publication-title: Ann Neurol – volume: 11 start-page: 357 year: 2017 end-page: 367 article-title: Cognitive reserve and cortical thickness in preclinical Alzheimer's disease publication-title: Brain Imaging Behav – volume: 73 start-page: 1230 issue: 12 year: 2016 end-page: 1237 article-title: Association of higher cortical amyloid burden with loneliness in cognitively normal older adults publication-title: JAMA Psychiatry – volume: 36 start-page: 1795 issue: 11 year: 2021 end-page: 1809 article-title: Social isolation, social support, loneliness and cardiovascular disease risk factors: a cross‐sectional study among older adults publication-title: Int J Geriatr Psychiatry – ident: e_1_2_8_14_1 doi: 10.3233/JAD-231218 – ident: e_1_2_8_33_1 doi: 10.1212/WNL.0000000000011375 – ident: e_1_2_8_29_1 doi: 10.1016/j.annemergmed.2010.06.560 – ident: e_1_2_8_30_1 doi: 10.1212/01.wnl.0000172958.95282.2a – ident: e_1_2_8_34_1 doi: 10.1016/0167-5273(87)90029-5 – ident: e_1_2_8_11_1 doi: 10.1089/rej.2010.1103 – ident: e_1_2_8_41_1 doi: 10.1002/alz.12362 – ident: e_1_2_8_31_1 doi: 10.1093/ajcn/36.5.936 – ident: e_1_2_8_38_1 doi: 10.1038/s43587-023-00387-0 – ident: e_1_2_8_18_1 doi: 10.1212/WNL.0000000000002914 – ident: e_1_2_8_4_1 doi: 10.1016/S1474-4422(20)30039-9 – ident: e_1_2_8_20_1 doi: 10.1177/2158244012461923 – ident: e_1_2_8_15_1 doi: 10.1016/j.jacc.2021.04.035 – ident: e_1_2_8_7_1 doi: 10.1016/j.neurobiolaging.2018.06.012 – ident: e_1_2_8_12_1 doi: 10.1016/j.jagp.2019.05.005 – ident: e_1_2_8_35_1 doi: 10.1016/j.amjcard.2010.01.340 – ident: e_1_2_8_10_1 doi: 10.1007/s11682-016-9581-y – ident: e_1_2_8_39_1 doi: 10.1001/jamaneurol.2017.0244 – ident: e_1_2_8_36_1 doi: 10.1016/j.neurobiolaging.2017.06.016 – ident: e_1_2_8_23_1 doi: 10.1016/j.atherosclerosis.2021.04.020 – ident: e_1_2_8_3_1 doi: 10.1016/j.arr.2023.101986 – ident: e_1_2_8_16_1 doi: 10.1016/j.dadm.2015.12.002 – ident: e_1_2_8_9_1 doi: 10.3233/JAD‐201426 – ident: e_1_2_8_37_1 doi: 10.1016/j.tics.2011.09.004 – ident: e_1_2_8_22_1 doi: 10.1093/geront/46.4.503 – ident: e_1_2_8_8_1 doi: 10.1093/ageing/afw060 – ident: e_1_2_8_40_1 doi: 10.1002/alz.13016 – ident: e_1_2_8_24_1 doi: 10.1161/STROKEAHA.114.005815 – ident: e_1_2_8_32_1 doi: 10.1093/ije/24.4.685 – ident: e_1_2_8_13_1 doi: 10.1001/jamapsychiatry.2016.2657 – ident: e_1_2_8_6_1 doi: 10.1097/YCO.0000000000000779 – ident: e_1_2_8_17_1 doi: 10.1161/STROKEAHA.114.007847 – ident: e_1_2_8_19_1 doi: 10.1111/j.1559-1816.1983.tb02325.x – ident: e_1_2_8_5_1 doi: 10.1146/annurev-psych-122216-011902 – ident: e_1_2_8_21_1 doi: 10.1097/00003727-198811000-00008 – ident: e_1_2_8_27_1 doi: 10.1016/j.jalz.2010.03.004 – ident: e_1_2_8_2_1 doi: 10.1002/ana.25380 – ident: e_1_2_8_25_1 doi: 10.1002/gps.5601 – volume-title: Administration for Community Living Office of Performance and Evaluation year: 2021 ident: e_1_2_8_26_1 – ident: e_1_2_8_28_1 doi: 10.1002/ana.26447 |
| SSID | ssj0001492410 |
| Score | 2.3061674 |
| Snippet | INTRODUCTION
This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden.
METHODS
Participants in... This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden. Participants in the Atherosclerosis... This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.INTRODUCTIONThis study aimed to... Abstract INTRODUCTION This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden. METHODS... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e12560 |
| SubjectTerms | amyloid beta Atherosclerosis Risk in Communities study dementia mid‐life positron emission tomography social relationships |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ1Lb9QwEMdHqOqBCwKVR3hURnABERo7jh_clj5UJFRVqEi9WeNH1FSQVrstZz4Cn5FPUj92V7uiggs3J7GUeMbR_CcZ_wzw2tqW9lG01Q0KrDnzWKMMPLYSTosnnEpG5n-WR0fq9FQfr2z1lWrCCh64GG6H0yCQ2t4JDFxzr0Xoe8uYtVJxq_I68qh6VpKp86L7Y2hqljxStuPRs_c0Bfi1CJRB_bepyz-LJFfFa44-B_fh3lw2kkl53AdwJ4xbcFjW1pLpoqDtbLicvSP4PSbhgyc2r1CIx6MnPn8FHPADifOCTL582v3989fx_gnJeNmH8PVg_2T3sJ7vjFC7LlUyBKUwZjpRqnkrGMYQ3inJXSOYjXIs1TcFalve-bbnrsUg-tBJxI4GGVhKGR7BxngxhidAusCd8g2yJiAXKLSWVGvHuRXBWaEreLOwlnFzbHjaveKbKcBjZpJlTbZsBa-WfS8LLOPWXh-T0Zc9EuA6n4huN3O3m3-5vYKXC5eZ-EKkvxw4hovrmYkxuU06WKoKHhcXLm_Vqk4mhGIFas25a8-yfmUczjJ0mzZaKUpFBW_zPPjLAM3eZI_l1tP_MdRncJdFJVXKhZ7DxtX0OryATffjaphNt_O8vwEBgQes priority: 102 providerName: Directory of Open Access Journals |
| Title | Social relationships, amyloid burden, and dementia: The ARIC‐PET study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdad2.12560 https://www.ncbi.nlm.nih.gov/pubmed/38571965 https://www.proquest.com/docview/3033008078 https://pubmed.ncbi.nlm.nih.gov/PMC10988116 https://doaj.org/article/41e6a1bfc6ae494d96effb22bb784b87 |
| Volume | 16 |
| WOSCitedRecordID | wos001195607800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: M~E dateStart: 20150101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: 7X7 dateStart: 20150901 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: 7RV dateStart: 20150901 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: BENPR dateStart: 20150901 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: PIMPY dateStart: 20150901 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: WIN dateStart: 20150101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 2352-8729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001492410 issn: 2352-8729 databaseCode: 24P dateStart: 20150101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VlgMXHuKVAqsguIBYGjuOH4jLtt2qK8EqWhVYTtE4dmgkmq12W878BH4jvwTb2c2yokJCXCw7mSixM5P5PBl_BniudUoqB9r6CXLsM2qwj8IyV_N0WszTqQTK_HdiPJbTqcq34O1qLUzLD9EF3LxlhO-1N3DUi701aahBQ18T77GvwQ4hqfQbN1CWryMszM0tAh0BdSjDmT1VHT8p3VtfvuGRAnH_VWjzz6TJ38Fs8EZHt_6vH7fh5hKFxoNWbe7Alm3uwnG7VDeer_LjTuvzxasYz9ycvjaxDgseXLsxsQlBxRrfxE7N4sFkdPDz-498eBIHttp78OFoeHJw3F9utNAvM58YYaVEN3FyyM9oTtEhgkwKViacaofufLqUJTplmUkrVqZoeWUzgZgRKyz1M5D7sN3MGvsQ4syyUpoEaWKRceRKCaJUyZjmttRcRfBiNdhFuWQh95thfC1a_mRa-PEownhE8KyTPW-5N66U2vfvrJPwfNnhwGz-pViaX8GI5Uh0VXK0TDGjuK0qTanWQjItRQRPV2-8cPblf5pgY2eXi8K5-NTDaiEjeNBqQHerVGbCMzJGIDd0Y-NZNs809Wng8CaJkpIQHsHLoBx_6WBxODikobb7L8KP4AZ1AKzNMnoM2xfzS_sErpffLurFvBdMxZVi8tGXUxFK2YOd_eE4n_RCbMK18tH7_LNrfRqNfwE_nhwA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BQaKXAuLR8DSCC4jQ2HH84Lb0oV2xrCq0iN4sO3baSCVb7bY98xP4jfwSbCebZUWFhLg5yUSJ7ZnMN5PxZ4BXxuS48qAtzTTTKSVWp5o76luBTosGOpVImT_mk4k4OpKHXW1OWAvT8kP0CbdgGfF7HQw8JKR3VqyhVlvyDgeXfR1uUI80ws4NX0eTVYqF-uAi8hEQDzO83RPZE5SSndXtay4pMvdfBTf_rJr8Hc1Gd3Rw-z87cge2OhyKBq3i3IVrrrkHw3axLpovK-RO6rPFW6S_-ai-tsjEJQ_-uLHIxrRird8jr2ho8Hm0-_P7j8P9KYp8tffhy8H-dHeYdlstpGURSiOcENqHTh77WcOI9pigEJyWGSPG47tQMOWwyWlh84qWuXascgXXusCOOxJikAew0cwatw2ocLQUNtMkc5oyzaTkWMqSUsNcaZhM4PVytFXZ8ZCH7TBOVcugTFQYDxXHI4GXvexZy75xpdSHMGm9RGDMjidm82PVGaCi2DGNTVUy7aikVjJXVYYQY7igRvAEXiynXHkLC79NdONmFwvlnXwegDUXCTxsVaB_VC4KHjgZExBryrH2LutXmvoksnjjTAqBMUvgTdSOv3RQ7Q32SGw9-hfh53BrOP00VuPR5ONj2CQejrU1R09g43x-4Z7CzfLyvF7Mn0W7-QUZ4hg5 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BQYgLD_EKTyO4gAiNHccPbku3q1ZUqxUqUm-WX6GRILvabTnzE_iN_BJsJ5tlRYWEuDnJRIntmcw3zsxngJfGlLgOoC0vNNM5JU7nmnsaWpFOi0Y6lUSZf8SnU3FyImd9bk6shen4IYYFt2gZ6XsdDdwvXL27YQ112pG3OLrsy3CFVhxHpSZ0tllioSG4SHwEJMCMYPdEDgSlZHdz-5ZLSsz9F8HNP7Mmf0ezyR1Nbv5nR27BjR6HolGnOLfhkm_vwEFXrIuW6wy502axeoP01xDVNw6ZVPIQjluHXFpWbPQ7FBQNjT4e7v38_mO2f4wSX-1d-DTZP947yPutFnJbxdQIL4QOoVPAfs4wogMmqASntmDEBHwXE6Y8NiWtXFlTW2rPal9xrSvsuScxBrkHO-289Q8AVZ5a4QpNCq8p00zKMDPSUmqYt4bJDF6tR1vZnoc8bofxRXUMykTF8VBpPDJ4McguOvaNC6Xex0kbJCJjdjoxX35WvQEqij3T2NSWaU8ldZL5ujaEGMMFNYJn8Hw95SpYWPxtols_P1-p4OTLCKy5yOB-pwLDo0oR9Y5VGYgt5dh6l-0rbXOaWLxxIYXAmGXwOmnHXzqoxqMxSa2H_yL8DK7NxhN1dDj98Aiuk4DGupSjx7Bztjz3T-Cq_XbWrJZPk9n8AvQmF1A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Social+relationships%2C+amyloid+burden%2C+and+dementia%3A+The+ARIC%E2%80%90PET+study&rft.jtitle=Alzheimer%27s+%26+dementia+%3A+diagnosis%2C+assessment+%26+disease+monitoring&rft.au=Groechel%2C+Ren%C3%A9e+C.&rft.au=Liu%2C+Albert+C.&rft.au=Liu%2C+Chelsea&rft.au=Knopman%2C+David+S.&rft.date=2024-04-01&rft.issn=2352-8729&rft.eissn=2352-8729&rft.volume=16&rft.issue=2&rft.epage=n%2Fa&rft_id=info:doi/10.1002%2Fdad2.12560&rft.externalDBID=10.1002%252Fdad2.12560&rft.externalDocID=DAD212560 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-8729&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-8729&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-8729&client=summon |