Social relationships, amyloid burden, and dementia: The ARIC‐PET study

INTRODUCTION This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden. METHODS Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measur...

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Vydané v:Alzheimer's & dementia : diagnosis, assessment & disease monitoring Ročník 16; číslo 2; s. e12560 - n/a
Hlavní autori: Groechel, Renée C., Liu, Albert C., Liu, Chelsea, Knopman, David S., Koton, Silvia, Kucharska‐Newton, Anna M., Lutsey, Pamela L., Mosley, Thomas H., Palta, Priya, Sharrett, A. Richey, Walker, Keenan A., Wong, Dean F., Gottesman, Rebecca F.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States John Wiley and Sons Inc 01.04.2024
Wiley
Predmet:
amyloid beta
Atherosclerosis Risk in Communities study
dementia
mid‐life
positron emission tomography
social relationships
dementia
mid‐life
social relationships
positron emission tomography
Atherosclerosis Risk in Communities study
amyloid beta
ISSN:2352-8729, 2352-8729
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Shrnutí:INTRODUCTION This study aimed to assess whether social relationships in mid‐life reduce the risk of dementia related to amyloid burden. METHODS Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990–1992). A composite measure, “social relationships,” was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012–2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid‐life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models. RESULTS Among 310 participants without dementia, strong mid‐life social relationships were associated independently with lower dementia risk. Elevated late‐life brain amyloid was associated with greater dementia risk. DISCUSSION Although mid‐life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.
Bibliografia:ObjectType-Article-1
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content type line 23
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12560