Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study

Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]) mediate the association. Methods: Subjects we...

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Veröffentlicht in:Annals of neurology Jg. 70; H. 5; S. 774 - 780
Hauptverfasser: Launer, Lenore J., Hughes, Timothy M., White, Lon R.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2011
Wiley-Liss
Wiley Subscription Services, Inc
Schlagworte:
Aged
Aged, 80 and over
Aging - ethnology
Aging - pathology
Aging - psychology
Alzheimer's disease
Asian
Atrophy
Autopsy
Biological and medical sciences
Brain
Brain - pathology
Brain Infarction - ethnology
Brain Infarction - pathology
Brain Infarction - psychology
Cognition
Cognitive ability
Cohort Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Hawaii
Humans
Male
Medical sciences
Neurofibrillary Tangles - pathology
Neurology
Organ Size
Plaque, Amyloid - ethnology
Plaque, Amyloid - pathology
Hawaii
Atrophy
Nervous system diseases
Senescence
Autopsy
Central nervous system
Encephalon
ISSN:0364-5134, 1531-8249, 1531-8249
Online-Zugang:Volltext
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Zusammenfassung:Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]) mediate the association. Methods: Subjects were 436 well‐characterized male decedents from the Honolulu Asia Aging Autopsy Study. Brain pathology was ascertained with standardized methods, CF was measured by the Cognitive Abilities Screening Instrument, and data were analyzed using formal mediation analyses, adjusted for age at death, time between last CF measure and death, education, and head size. Based on antemortem diagnoses, demented and nondemented subjects were examined together and separately. Results: In those with no dementia, MBIs were strongly associated with the last antemortem CF score; this was significantly mediated by BW, and not NFTs or NPs. In contrast, among those with an antemortem diagnosis of dementia, NFTs had the strongest associations with BW and with CF, and MBIs were modestly associated with CF. Interpretation: This suggests that microinfarct pathology is a significant and independent factor contributing to brain atrophy and cognitive impairment, particularly before dementia is clinically evident. The role of vascular damage as initiator, stimulator, or additive contributor to neurodegeneration may differ depending on when in the trajectory toward dementia the lesions develop. ANN NEUROL 2011
Bibliographie:ArticleID:ANA22520
NIH National Institute on Aging (NIA) - No. 1 U01 AG19349; No. 5 R01 AG017155
ark:/67375/WNG-TXFLX7JP-X
NIA Intramural Research Program
istex:138D7F354E7CFB8D34752964E1AA7C03B5B12EA6
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ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.22520