Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata

In this study, for the first time, we discovered novel water-soluble carbon dots (CDs, named CSC-CDs) from aqueous extracts of Cirsium setosum Carbonisata (CSC), which were uniform in size and possessed a nearly spherical shape, and the CDs exhibited low toxicity against RAW 264.7 cells by CCK-8 ass...

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Veröffentlicht in:RSC advances Jg. 8; H. 66; S. 3777 - 37714
Hauptverfasser: Luo, Juan, Zhang, Meiling, Cheng, Jinjun, Wu, Shuhong, Xiong, Wei, Kong, Hui, Zhao, Yan, Qu, Huihua
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Royal Society of Chemistry 09.11.2018
The Royal Society of Chemistry
Schlagworte:
Bleeding
Blood coagulation
Carbon
Carbon dots
carbon quantum dots
Chemistry
Cirsium arvense
coagulation
Fibrinogen
hemorrhage
Liver
Mice
tail
Toxicity
water solubility
ISSN:2046-2069, 2046-2069
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Zusammenfassung:In this study, for the first time, we discovered novel water-soluble carbon dots (CDs, named CSC-CDs) from aqueous extracts of Cirsium setosum Carbonisata (CSC), which were uniform in size and possessed a nearly spherical shape, and the CDs exhibited low toxicity against RAW 264.7 cells by CCK-8 assay. Most importantly, tail hemorrhaging and liver hemorrhaging experiments showed that CSC-CD-treated mice had significantly shorter bleeding times than normal saline-treated mice. Coagulation assays suggested that the CSC-CDs could stimulate the extrinsic blood coagulation system and activate the fibrinogen system. These results suggested that the CSC-CDs have a remarkable hemostatic effect. The study provides evidence to support the further investigation of the considerable potential of carbon dots. We discovered novel water-soluble carbon dots from aqueous extracts of Cirsium setosum Carbonisata, which have a remarkable hemostatic effect. The study provides evidence to support the further investigation of considerable potential of carbon dots.
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ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra06340k