Chlamydophila pneumoniae phospholipase D (CpPLD) drives Th17 inflammation in human atherosclerosis

Phospholipases are produced from bacterial pathogens causing very different diseases. One of the most intriguing aspects of phospholipases is their potential to interfere with cellular signaling cascades and to modulate the host-immune response. Here, we investigated the role of the innate and acqui...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 4; S. 1222
Hauptverfasser:	Benagiano, Marisa, Munari, Fabio, Ciervo, Alessandra, Amedei, Amedeo, Paccani, Silvia Rossi, Mancini, Fabiola, Ferrari, Mauro, Della Bella, Chiara, Ulivi, Camilla, D'Elios, Sofia, Baldari, Cosima T, Prisco, Domenico, de Bernard, Marina, D'Elios, Mario M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 24.01.2012
Schlagworte:	Aged Atherosclerosis - immunology Atherosclerosis - microbiology Cell Line Chemokines - immunology Chlamydophila pneumoniae - enzymology Cytokines - immunology Enzyme-Linked Immunosorbent Assay Female Gene Expression Regulation - immunology Human Umbilical Vein Endothelial Cells Humans Male Matrix Metalloproteinase 9 - metabolism Middle Aged Monocytes - immunology Phospholipase D - immunology Phospholipase D - pharmacology Real-Time Polymerase Chain Reaction Th17 Cells - immunology Thromboplastin - metabolism Toll-Like Receptor 4 - agonists
ISSN:	1091-6490, 1091-6490
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