The cGAS-STING pathway for DNA sensing

The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms o...

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Veröffentlicht in:Molecular cell Jg. 51; H. 2; S. 135
Hauptverfasser: Xiao, T Sam, Fitzgerald, Katherine A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 25.07.2013
Schlagworte:
Biosensing Techniques
DNA - metabolism
Humans
Membrane Proteins - metabolism
Nucleotidyltransferases - metabolism
Second Messenger Systems
ISSN:1097-4164, 1097-4164
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Zusammenfassung:The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms of cGAMP generation. Concurrent studies also reveal unique phosphodiester linkages in endogenous cGAMP that distinguish it from microbial cGAMP and other cyclic dinucleotides. Together, these studies provide a new perspective on DNA recognition in the innate immune system.
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ISSN:1097-4164
1097-4164
DOI:10.1016/j.molcel.2013.07.004