Genomic Evaluation of the Genus Coltivirus Indicates Genetic Diversity among Colorado Tick Fever Virus Strains and Demarcation of a New Species

The type species of the genus Coltivirus, Colorado tick fever virus (CTFV), was discovered in 1943 and is the most common tick-borne viral infection in the Western US. Despite its long history, very little is known about the molecular diversity of viruses classified within the species Colorado tick...

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Bibliographic Details
Published in:Diseases Vol. 9; no. 4; p. 92
Main Authors: Hughes, Holly R., Velez, Jason O., Fitzpatrick, Kelly, Davis, Emily H., Russell, Brandy J., Lambert, Amy J., Staples, J. Erin, Brault, Aaron C.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 17.12.2021
MDPI
Subjects:
Amino acids
Arachnids
Cell culture
Colorado tick fever
Colorado tick fever virus
Coltivirus
Disease
Fever
Genetic diversity
Genomes
Genomics
New species
Nucleotide sequence
Phylogenetics
phylogeny
Reading
Serotypes
Strains (organisms)
Trees
Viruses
whole genome sequencing
United States > US
Salmon River
Colorado
Colorado tick fever virus
whole genome sequencing
phylogeny
Coltivirus
ISSN:2079-9721, 2079-9721
Online Access:Get full text
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Summary:The type species of the genus Coltivirus, Colorado tick fever virus (CTFV), was discovered in 1943 and is the most common tick-borne viral infection in the Western US. Despite its long history, very little is known about the molecular diversity of viruses classified within the species Colorado tick fever coltivirus. Previous studies have suggested genetic variants and potential serotypes of CTFV, but limited genetic sequence information is available for CTFV strains. To address this knowledge gap, we report herein the full-length genomes of five strains of CTFV, including Salmon River virus and California hare coltivirus (CTFV-Ca). The sequence from the full-length genome of Salmon River virus identified a high genetic identity to the CTFV prototype strain with >90% amino acid identity in all the segments except segment four, suggesting Salmon River virus is a strain of the species Colorado tick fever coltivirus. Additionally, analysis suggests that segment four has been associated with reassortment in at least one strain. The CTFV-Ca full-length genomic sequence was highly variable from the prototype CTFV in all the segments. The genome of CTFV-Ca was most similar to the Eyach virus, including similar segments six and seven. These data suggest that CTFV-Ca is not a strain of CTFV but a unique species. Additional sequence information of CTFV strains will improve the molecular surveillance tools and provide additional taxonomic resolution to this understudied virus.
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ISSN:2079-9721
2079-9721
DOI:10.3390/diseases9040092