ISTH guidelines for antithrombotic treatment in COVID‐19

Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID‐19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, I...

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Veröffentlicht in:Journal of thrombosis and haemostasis Jg. 20; H. 10; S. 2214 - 2225
Hauptverfasser: Schulman, Sam, Sholzberg, Michelle, Spyropoulos, Alex C., Zarychanski, Ryan, Resnick, Helaine E., Bradbury, Charlotte A., Connors, Jean Marie, Falanga, Anna, Iba, Toshiaki, Kaatz, Scott, Levy, Jerrold H., Middeldorp, Saskia, Minichiello, Tracy, Ramacciotti, Eduardo, Samama, Charles Marc, Thachil, Jecko, Broxmeyer, Lisa, International Society on Thrombosis and Haemostasis
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Inc 01.10.2022
Elsevier Limited
John Wiley and Sons Inc
Schlagworte:
Aftercare
anticoagulants
Anticoagulants - adverse effects
Coronaviruses
COVID-19
critical illness
Dosage
Fibrinolytic Agents - adverse effects
Heparin
Heparin - adverse effects
Heparin, Low-Molecular-Weight
Hospitalization
Humans
Molecular weight
Patient Discharge
Patients
platelet aggregation inhibitors
Platelet Aggregation Inhibitors - adverse effects
Recommendations and Guidelines
Rivaroxaban
Thromboembolism
anticoagulants
COVID‐19
critical illness
platelet aggregation inhibitors
COVID-19
ISSN:1538-7836, 1538-7933, 1538-7836
Online-Zugang:Volltext
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Abstract Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID‐19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, ISTH assembled an international panel of content experts, patient representatives, and a methodologist to develop recommendations on anticoagulants and antiplatelet agents for patients with COVID‐19 in different clinical settings. We used the American College of Cardiology Foundation/American Heart Association methodology to assess level of evidence (LOE) and class of recommendation (COR). Only recommendations with LOE A or B were included. Panelists agreed on 12 recommendations: three for non‐hospitalized, five for non–critically ill hospitalized, three for critically ill hospitalized, and one for post‐discharge patients. Two recommendations were based on high‐quality evidence, the remainder on moderate‐quality evidence. Among non–critically ill patients hospitalized for COVID‐19, the panel gave a strong recommendation (a) for use of prophylactic dose of low molecular weight heparin or unfractionated heparin (LMWH/UFH) (COR 1); (b) for select patients in this group, use of therapeutic dose LMWH/UFH in preference to prophylactic dose (COR 1); but (c) against the addition of an antiplatelet agent (COR 3). Weak recommendations favored (a) sulodexide in non‐hospitalized patients, (b) adding an antiplatelet agent to prophylactic LMWH/UFH in select critically ill, and (c) prophylactic rivaroxaban for select patients after discharge (all COR 2b). Recommendations in this guideline are based on high‐/moderate‐quality evidence available through March 2022. Focused updates will incorporate future evidence supporting changes to these recommendations.
AbstractList Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID-19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, ISTH assembled an international panel of content experts, patient representatives, and a methodologist to develop recommendations on anticoagulants and antiplatelet agents for patients with COVID-19 in different clinical settings. We used the American College of Cardiology Foundation/American Heart Association methodology to assess level of evidence (LOE) and class of recommendation (COR). Only recommendations with LOE A or B were included. Panelists agreed on 12 recommendations: three for non-hospitalized, five for non-critically ill hospitalized, three for critically ill hospitalized, and one for post-discharge patients. Two recommendations were based on high-quality evidence, the remainder on moderate-quality evidence. Among non-critically ill patients hospitalized for COVID-19, the panel gave a strong recommendation (a) for use of prophylactic dose of low molecular weight heparin or unfractionated heparin (LMWH/UFH) (COR 1); (b) for select patients in this group, use of therapeutic dose LMWH/UFH in preference to prophylactic dose (COR 1); but (c) against the addition of an antiplatelet agent (COR 3). Weak recommendations favored (a) sulodexide in non-hospitalized patients, (b) adding an antiplatelet agent to prophylactic LMWH/UFH in select critically ill, and (c) prophylactic rivaroxaban for select patients after discharge (all COR 2b). Recommendations in this guideline are based on high-/moderate-quality evidence available through March 2022. Focused updates will incorporate future evidence supporting changes to these recommendations.Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID-19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, ISTH assembled an international panel of content experts, patient representatives, and a methodologist to develop recommendations on anticoagulants and antiplatelet agents for patients with COVID-19 in different clinical settings. We used the American College of Cardiology Foundation/American Heart Association methodology to assess level of evidence (LOE) and class of recommendation (COR). Only recommendations with LOE A or B were included. Panelists agreed on 12 recommendations: three for non-hospitalized, five for non-critically ill hospitalized, three for critically ill hospitalized, and one for post-discharge patients. Two recommendations were based on high-quality evidence, the remainder on moderate-quality evidence. Among non-critically ill patients hospitalized for COVID-19, the panel gave a strong recommendation (a) for use of prophylactic dose of low molecular weight heparin or unfractionated heparin (LMWH/UFH) (COR 1); (b) for select patients in this group, use of therapeutic dose LMWH/UFH in preference to prophylactic dose (COR 1); but (c) against the addition of an antiplatelet agent (COR 3). Weak recommendations favored (a) sulodexide in non-hospitalized patients, (b) adding an antiplatelet agent to prophylactic LMWH/UFH in select critically ill, and (c) prophylactic rivaroxaban for select patients after discharge (all COR 2b). Recommendations in this guideline are based on high-/moderate-quality evidence available through March 2022. Focused updates will incorporate future evidence supporting changes to these recommendations.
Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID-19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, ISTH assembled an international panel of content experts, patient representatives, and a methodologist to develop recommendations on anticoagulants and antiplatelet agents for patients with COVID-19 in different clinical settings. We used the American College of Cardiology Foundation/American Heart Association methodology to assess level of evidence (LOE) and class of recommendation (COR). Only recommendations with LOE A or B were included. Panelists agreed on 12 recommendations: three for non-hospitalized, five for non-critically ill hospitalized, three for critically ill hospitalized, and one for post-discharge patients. Two recommendations were based on high-quality evidence, the remainder on moderate-quality evidence. Among non-critically ill patients hospitalized for COVID-19, the panel gave a strong recommendation (a) for use of prophylactic dose of low molecular weight heparin or unfractionated heparin (LMWH/UFH) (COR 1); (b) for select patients in this group, use of therapeutic dose LMWH/UFH in preference to prophylactic dose (COR 1); but (c) against the addition of an antiplatelet agent (COR 3). Weak recommendations favored (a) sulodexide in non-hospitalized patients, (b) adding an antiplatelet agent to prophylactic LMWH/UFH in select critically ill, and (c) prophylactic rivaroxaban for select patients after discharge (all COR 2b). Recommendations in this guideline are based on high-/moderate-quality evidence available through March 2022. Focused updates will incorporate future evidence supporting changes to these recommendations.
Author Minichiello, Tracy
Broxmeyer, Lisa
Bradbury, Charlotte A.
Zarychanski, Ryan
Samama, Charles Marc
Spyropoulos, Alex C.
Falanga, Anna
Schulman, Sam
Iba, Toshiaki
Thachil, Jecko
Kaatz, Scott
Resnick, Helaine E.
Levy, Jerrold H.
Ramacciotti, Eduardo
Connors, Jean Marie
International Society on Thrombosis and Haemostasis
Sholzberg, Michelle
Middeldorp, Saskia
AuthorAffiliation 3 Departments of Medicine, and Laboratory Medicine and Pathobiology St Michael's Hospital Li Ka Shing Knowledge Institute University of Toronto Toronto Ontario Canada
1 Department of Medicine Thrombosis and Atherosclerosis Research Institute McMaster University Hamilton Ontario Canada
11 University of Milan Bicocca Monza Italy
15 Department of Internal Medicine and Radboud Institute of Health Sciences Radboud University Medical Centre Nijmegen the Netherlands
9 Division of Hematology Brigham and Women's Hospital Boston Massachusetts USA
19 Department of Anaesthesia Centre—Université de Paris—Cochin Hospital Intensive Care and Perioperative Medicine GHU AP‐HP Paris France
2 Department of Obstetrics and Gynecology I.M. Sechenov First Moscow State Medical University Moscow Russia
17 Science Valley Research Institute São Paulo Brazil
14 Departments of Anesthesiology, Critical Care, and Surgery (Cardiothoracic) Duke University School of Medicine Durham North Carolina USA
7 Resnick, Chodorow & Associ
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– name: 19 Department of Anaesthesia Centre—Université de Paris—Cochin Hospital Intensive Care and Perioperative Medicine GHU AP‐HP Paris France
– name: 11 University of Milan Bicocca Monza Italy
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– name: 8 Faculty of Health Sciences University of Bristol Bristol UK
– name: 9 Division of Hematology Brigham and Women's Hospital Boston Massachusetts USA
– name: 17 Science Valley Research Institute São Paulo Brazil
– name: 4 Institute of Health System Science Feinstein Institutes for Medical Research, Northwell Health Manhasset New York USA
– name: 20 Department of Haematology Manchester University Hospitals Manchester UK
– name: 7 Resnick, Chodorow & Associates Silver Spring Maryland USA
– name: 10 Department of Transfusion Medicine and Hematology Hospital Papa Giovanni XXIII Bergamo Italy
– name: 15 Department of Internal Medicine and Radboud Institute of Health Sciences Radboud University Medical Centre Nijmegen the Netherlands
– name: 18 Hospital e Maternidade Christóvão da Gama Grupo Leforte Santo André São Paulo Brazil
– name: 2 Department of Obstetrics and Gynecology I.M. Sechenov First Moscow State Medical University Moscow Russia
– name: 16 Division of Hematology San Francisco VA Medical Center University of California, San Francisco San Francisco California USA
– name: 6 Sections of Hematology/Oncology and Critical Care University of Manitoba Winnipeg Manitoba Canada
– name: 13 Division of Hospital Medicine Henry Ford Hospital Detroit Michigan USA
– name: 5 Department of Medicine Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead New York USA
– name: 12 Department of Emergency and Disaster Medicine Juntendo University Tokyo Japan
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  surname: Sholzberg
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  orcidid: 0000-0001-5248-8165
  surname: Bradbury
  fullname: Bradbury, Charlotte A.
  organization: Faculty of Health Sciences, University of Bristol, Bristol, UK
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  orcidid: 0000-0001-6445-582X
  surname: Connors
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  surname: Falanga
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  surname: Levy
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  orcidid: 0000-0002-1675-4689
  surname: Minichiello
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  organization: Division of Hematology, San Francisco VA Medical Center, University of California, San Francisco, San Francisco, California, USA
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  givenname: Eduardo
  orcidid: 0000-0002-5735-1333
  surname: Ramacciotti
  fullname: Ramacciotti, Eduardo
  organization: Science Valley Research Institute, São Paulo, Brazil
– sequence: 15
  givenname: Charles Marc
  orcidid: 0000-0003-0460-6491
  surname: Samama
  fullname: Samama, Charles Marc
  organization: Department of Anaesthesia, Centre—Université de Paris—Cochin Hospital, Intensive Care and Perioperative Medicine GHU AP‐HP, Paris, France
– sequence: 16
  givenname: Jecko
  orcidid: 0000-0001-7218-0993
  surname: Thachil
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  orcidid: 0000-0001-6125-2322
  surname: Broxmeyer
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– sequence: 18
  surname: International Society on Thrombosis and Haemostasis
  fullname: International Society on Thrombosis and Haemostasis
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35906716$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1001/jama.2021.4152
10.1111/jth.14929
10.1055/a-1366-9656
10.1016/S0140-6736(21)01825-0
10.1111/j.1538-7836.2010.04044.x
10.1111/joim.13205
10.1002/rth2.12638
10.1016/S0140-6736(21)02392-8
10.1016/j.diabres.2022.109232
10.1016/j.eclinm.2021.101139
10.1371/journal.pone.0246825
10.1093/cvr/cvab308
10.1182/blood.2020010529
10.1055/a-1485-2372
10.1055/a-1414-5216
10.1056/NEJMoa1014475
10.1111/jth.13140
10.1111/j.1538-7836.2006.01818.x
10.1001/jama.2021.17272
10.1001/jama.2022.2910
10.1001/jama.2021.23605
10.1056/NEJMoa2103417
10.1016/j.thromres.2021.06.014
10.1056/NEJMoa2105911
10.1186/s13045-021-01185-0
10.1111/jth.15450
10.1111/jth.15809
10.1055/a-1347-6070
10.1016/S0140-6736(21)01203-4
10.1016/j.thromres.2020.09.026
10.1016/j.thromres.2021.12.010
10.1161/CIR.0b013e31827e8e5f
10.1016/j.jacc.2020.08.070
10.1007/s10557-020-07133-3
10.1161/01.CIR.0000138928.83266.24
10.1002/ajh.26102
10.1590/1516-3180.2021.0098.r1.08062021
10.1111/ejh.13533
10.1001/jamainternmed.2021.6203
10.1111/j.1538-7836.2005.01204.x
10.1007/s11739-021-02891-w
10.1002/rth2.12439
10.1056/NEJM199909093411103
10.1182/bloodadvances.2018022954
10.1111/jth.14810
10.1055/s-0037-1603929
10.1161/STR.0000000000000375
10.1016/j.jacc.2020.04.071
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Copyright 2022 International Society on Thrombosis and Haemostasis.
2022 International Society on Thrombosis and Haemostasis
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Issue 10
Keywords anticoagulants
COVID‐19
critical illness
platelet aggregation inhibitors
COVID-19
Language English
License 2022 International Society on Thrombosis and Haemostasis.
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
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Notes Manuscript handled by: Walter Ageno
Final decision: Walter Ageno, 05 July 2022
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References Lawler, Goligher, Berger (bb0150) 2021; 385
Di Castelnuovo, Costanzo, Antinori (bb0115) 2021; 121
Osborne, Veigulis, Arreola, Mahajan, Röösli, Curtin (bb0080) 2021; 16
Sholzberg, da Costa, Tang (bb0155) 2021; 5
Morici, Podda, Birocchi (bb0170) 2021; 52
Cucinotta, Vanelli (bb0010) 2020; 91
Leizorovicz, Cohen, Turpie, Olsson, Vaitkus, Goldhaber (bb0210) 2004; 110
Higgins, Savovic, Page, Elbers, Sterne (bb0045) 2022
Battistoni, Francioni, Morici (bb0105) 2021; 22
Lopes, de Barros, Furtado (bb0190) 2021; 397
Samama, Cohen, Darmon (bb0205) 1999; 341
Wong, Tomlinson, Brown (bb0300) 2021; 14
Nopp, Moik, Jilma, Pabinger, Ay (bb0200) 2020; 4
Spyropoulos, Ageno, Albers (bb0295) 2020; 75
Poli, Antonucci, Ageno, Prandoni, Palareti, Marcucci (bb0135) 2022; 17
Ionescu, Jaiyesimi, Petrescu (bb0120) 2021; 106
Lemos, do Espirito Santo, Salvetti (bb0270) 2020; 196
ACCF/AHA. Methodology Manual and Policies From the ACCF/AHA Task Force on Practice Guidelines.
Gonzalez‐Porras, Belhassen‐Garcia, Lopez‐Bernus (bb0160) 2022; 140
Goligher, Bradbury, McVerry (bb0245) 2021; 385
Abstrackr. Brown University, School of Public Health.
Piazza, Campia, Hurwitz (bb0070) 2020; 76
Jacobs, Kushner, Ettinger (bb0030) 2013; 127
Berger, Kornblith, Gong (bb0180) 2022; 327
Spyropoulos, Goldin, Giannis (bb0145) 2021; 181
Rentsch, Beckman, Tomlinson (bb0125) 2021; 372
Cook, Meade, Guyatt (bb0260) 2011; 364
[accessed 2022, March 17].
Kleindorfer, Towfighi, Chaturvedi (bb0305) 2021; 52
Spyropoulos, Levy, Ageno (bb0015) 2020; 18
Oliynyk, Barg, Slifirczyk (bb0250) 2021; 11
Gobierno de Mexico‐ IMSS. Calculadora de complicacion de salud por COVID‐19.
Montorfano, Leoni, Andreassi (bb0085) 2022
Barbar, Noventa, Rossetto (bb0215) 2010; 8
Perepu, Chambers, Wahab (bb0235) 2021; 19
[accessed 2022, June 10].
Bradbury, Lawler, Stanworth (bb0255) 2022; 327
Schulman, Kearon (bb0275) 2005; 3
Meizlish, Goshua, Liu (bb0165) 2021; 96
Giannis, Allen, Tsang (bb0280) 2021; 137
Schünemann, Cushman, Burnett (bb0265) 2018; 2
Gibson, Spyropoulos, Cohen (bb0225) 2017; 1
Connors, Brooks, Sciurba (bb0050) 2021; 326
Sadeghipour, Talasaz, Rashidi (bb0240) 2021; 325
Flam, Wintzell, Ludvigsson, Mårtensson, Pasternak (bb0055) 2021; 289
Shen, Qiu, Liu (bb0130) 2021; 36
Thachil, Tang, Gando (bb0020) 2020; 18
Gonzalez‐Ochoa, Raffetto, Hernández (bb0065) 2021; 121
Bikdeli, Talasaz, Rashidi (bb0230) 2021; 122
Smadja, Bonnet, Gendron (bb0175) 2021; 8
Ramacciotti, Barile Agati, Calderaro (bb0285) 2022; 399
Lui, Li, Lee (bb0290) 2022; 185
Kaatz, Ahmad, Spyropoulos, Schulman (bb0075) 2015; 13
Rivera‐Caravaca, Buckley, Harrison (bb0060) 2021; 205
Spyropoulos, Connors, Douketis (bb0025) 2022; 20
Abdel‐Qadir, Austin, Pang (bb0090) 2022; 211
Sholzberg, Tang, Rahhal (bb0140) 2021; 375
Cohen, Gianos, Barish (bb0110) 2021; 121
Pereyra, Heber, Schrottmaier (bb0195) 2021; 117
Hozayen, Zychowski, Benson (bb0095) 2021; 41
Chopard, Spirk, Bounameaux (bb0220) 2006; 4
(bb0185) 2022; 399
2022; 211
2017; 1
2021; 22
2021; 289
2013; 127
2021; 326
2021; 205
2021; 325
2022; 20
2021; 122
2021; 121
2020; 18
2021; 36
2020; 4
2018; 2
2021; 117
2020; 91
2021; 397
2021; 41
2022; 327
2011; 364
2010; 8
2015; 13
2021; 8
2021; 5
2021; 106
2021; 181
1999; 341
2006; 4
2020; 76
2021; 385
2021; 96
2021; 52
2022; 399
2021; 14
2021; 16
2004; 110
2022; 140
2022; 185
2021; 11
2020; 75
2022
2020; 196
2021; 137
2021; 19
2021; 372
2021; 375
2005; 3
2022; 17
Lemos (10.1111/jth.15808_bb0270) 2020; 196
Sholzberg (10.1111/jth.15808_bb0155) 2021; 5
Flam (10.1111/jth.15808_bb0055) 2021; 289
Lui (10.1111/jth.15808_bb0290) 2022; 185
Kleindorfer (10.1111/jth.15808_bb0305) 2021; 52
Kaatz (10.1111/jth.15808_bb0075) 2015; 13
Leizorovicz (10.1111/jth.15808_bb0210) 2004; 110
Shen (10.1111/jth.15808_bb0130) 2021; 36
Lawler (10.1111/jth.15808_bb0150) 2021; 385
Hozayen (10.1111/jth.15808_bb0095) 2021; 41
Meizlish (10.1111/jth.15808_bb0165) 2021; 96
10.1111/jth.15808_bb0040
Spyropoulos (10.1111/jth.15808_bb0015) 2020; 18
Piazza (10.1111/jth.15808_bb0070) 2020; 76
Ramacciotti (10.1111/jth.15808_bb0285) 2022; 399
Spyropoulos (10.1111/jth.15808_bb0295) 2020; 75
Smadja (10.1111/jth.15808_bb0175) 2021; 8
Morici (10.1111/jth.15808_bb0170) 2021; 52
10.1111/jth.15808_bb0035
Berger (10.1111/jth.15808_bb0180) 2022; 327
Bradbury (10.1111/jth.15808_bb0255) 2022; 327
Chopard (10.1111/jth.15808_bb0220) 2006; 4
Di Castelnuovo (10.1111/jth.15808_bb0115) 2021; 121
Gonzalez‐Porras (10.1111/jth.15808_bb0160) 2022; 140
Sadeghipour (10.1111/jth.15808_bb0240) 2021; 325
Gonzalez‐Ochoa (10.1111/jth.15808_bb0065) 2021; 121
Connors (10.1111/jth.15808_bb0050) 2021; 326
Sholzberg (10.1111/jth.15808_bb0140) 2021; 375
Thachil (10.1111/jth.15808_bb0020) 2020; 18
Spyropoulos (10.1111/jth.15808_bb0145) 2021; 181
Cucinotta (10.1111/jth.15808_bb0010) 2020; 91
10.1111/jth.15808_bb0100
Bikdeli (10.1111/jth.15808_bb0230) 2021; 122
Wong (10.1111/jth.15808_bb0300) 2021; 14
Rivera‐Caravaca (10.1111/jth.15808_bb0060) 2021; 205
Montorfano (10.1111/jth.15808_bb0085) 2022
Osborne (10.1111/jth.15808_bb0080) 2021; 16
Jacobs (10.1111/jth.15808_bb0030) 2013; 127
(10.1111/jth.15808_bb0185) 2022; 399
Spyropoulos (10.1111/jth.15808_bb0025) 2022; 20
Cook (10.1111/jth.15808_bb0260) 2011; 364
Cohen (10.1111/jth.15808_bb0110) 2021; 121
Oliynyk (10.1111/jth.15808_bb0250) 2021; 11
Schulman (10.1111/jth.15808_bb0275) 2005; 3
Higgins (10.1111/jth.15808_bb0045) 2022
Pereyra (10.1111/jth.15808_bb0195) 2021; 117
Nopp (10.1111/jth.15808_bb0200) 2020; 4
Perepu (10.1111/jth.15808_bb0235) 2021; 19
Battistoni (10.1111/jth.15808_bb0105) 2021; 22
Lopes (10.1111/jth.15808_bb0190) 2021; 397
Abdel‐Qadir (10.1111/jth.15808_bb0090) 2022; 211
Goligher (10.1111/jth.15808_bb0245) 2021; 385
Ionescu (10.1111/jth.15808_bb0120) 2021; 106
Poli (10.1111/jth.15808_bb0135) 2022; 17
Schünemann (10.1111/jth.15808_bb0265) 2018; 2
Giannis (10.1111/jth.15808_bb0280) 2021; 137
Samama (10.1111/jth.15808_bb0205) 1999; 341
Barbar (10.1111/jth.15808_bb0215) 2010; 8
Rentsch (10.1111/jth.15808_bb0125) 2021; 372
Gibson (10.1111/jth.15808_bb0225) 2017; 1
36271456 - J Thromb Haemost. 2022 Nov;20(11):2708-2709. doi: 10.1111/jth.15855
36271457 - J Thromb Haemost. 2022 Nov;20(11):2710-2711. doi: 10.1111/jth.15854
References_xml – volume: 205
  start-page: 1
  year: 2021
  end-page: 7
  ident: bb0060
  article-title: Direct‐acting oral anticoagulants use prior to COVID‐19 diagnosis and associations with 30‐day clinical outcomes
  publication-title: Thromb Res
– volume: 19
  start-page: 2225
  year: 2021
  end-page: 2234
  ident: bb0235
  article-title: Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID‐19: a multi‐center, open‐label, randomized controlled trial
  publication-title: J Thromb Haemost
– volume: 5
  year: 2021
  ident: bb0155
  article-title: Randomized trials of therapeutic heparin for COVID‐19: a meta‐analysis
  publication-title: Res Pract Thromb Haemost
– volume: 372
  year: 2021
  ident: bb0125
  article-title: Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
  publication-title: BMJ
– volume: 211
  start-page: 114
  year: 2022
  end-page: 122
  ident: bb0090
  article-title: The association between anticoagulation and adverse outcomes after a positive SARS‐CoV‐2 test among older outpatients: a population‐based cohort study
  publication-title: Thromb Res
– volume: 106
  start-page: 165
  year: 2021
  end-page: 174
  ident: bb0120
  article-title: Association of anticoagulation dose and survival in hospitalized COVID‐19 patients: a retrospective propensity score‐weighted analysis
  publication-title: Eur J Haematol
– volume: 36
  start-page: 113
  year: 2021
  end-page: 120
  ident: bb0130
  article-title: The association of low molecular weight heparin use and in‐hospital mortality among patients hospitalized with COVID‐19
  publication-title: Cardiovasc Drugs Ther
– volume: 375
  year: 2021
  ident: bb0140
  article-title: Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid‐19 admitted to hospital: RAPID randomised clinical trial
  publication-title: BMJ
– volume: 397
  start-page: 2253
  year: 2021
  end-page: 2263
  ident: bb0190
  article-title: Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID‐19 and elevated D‐dimer concentration (ACTION): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
– volume: 4
  start-page: 915
  year: 2006
  end-page: 916
  ident: bb0220
  article-title: Identifying acutely ill medical patients requiring thromboprophylaxis
  publication-title: J Thromb Haemost
– volume: 196
  start-page: 359
  year: 2020
  end-page: 366
  ident: bb0270
  article-title: Therapeutic versus prophylactic anticoagulation for severe COVID‐19: a randomized phase II clinical trial (HESACOVID)
  publication-title: Thromb Res
– volume: 121
  start-page: 944
  year: 2021
  end-page: 954
  ident: bb0065
  article-title: Sulodexide in the treatment of patients with early stages of COVID‐19: a randomized controlled trial
  publication-title: Thromb Haemost
– volume: 14
  start-page: 172
  year: 2021
  ident: bb0300
  article-title: Association between warfarin and COVID‐19‐related outcomes compared with direct oral anticoagulants: population‐based cohort study
  publication-title: J Hematol Oncol
– reference: Abstrackr. Brown University, School of Public Health.
– volume: 121
  start-page: 1054
  year: 2021
  end-page: 1065
  ident: bb0115
  article-title: Heparin in COVID‐19 patients is associated with reduced in‐hospital mortality: the multicenter Italian CORIST study
  publication-title: Thromb Haemost
– volume: 2
  start-page: 3198
  year: 2018
  end-page: 3225
  ident: bb0265
  article-title: American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients
  publication-title: Blood Adv
– volume: 327
  start-page: 1247
  year: 2022
  end-page: 1259
  ident: bb0255
  article-title: Effect of antiplatelet therapy on survival and organ support‐free days in critically ill patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
– volume: 181
  start-page: 1612
  year: 2021
  end-page: 1620
  ident: bb0145
  article-title: Efficacy and safety of therapeutic‐dose heparin vs standard prophylactic or intermediate‐dose heparins for thromboprophylaxis in high‐risk hospitalized patients with COVID‐19: the HEP‐COVID randomized clinical trial
  publication-title: JAMA Intern Med
– volume: 8
  year: 2021
  ident: bb0175
  article-title: Intermediate‐ vs. standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted in medical Ward: a propensity score‐matched cohort study
  publication-title: Front Med (Lausanne)
– volume: 341
  start-page: 793
  year: 1999
  end-page: 800
  ident: bb0205
  article-title: A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in medical patients with enoxaparin study group
  publication-title: N Engl J Med
– volume: 385
  start-page: 777
  year: 2021
  end-page: 789
  ident: bb0245
  article-title: Therapeutic anticoagulation with heparin in critically ill patients with Covid‐19
  publication-title: N Engl J Med
– volume: 18
  start-page: 1023
  year: 2020
  end-page: 1026
  ident: bb0020
  article-title: ISTH interim guidance on recognition and management of coagulopathy in COVID‐19
  publication-title: J Thromb Haemost
– volume: 385
  start-page: 790
  year: 2021
  end-page: 802
  ident: bb0150
  article-title: Therapeutic anticoagulation with heparin in noncritically ill patients with Covid‐19
  publication-title: N Engl J Med
– volume: 91
  start-page: 157
  year: 2020
  end-page: 160
  ident: bb0010
  article-title: WHO declares COVID‐19 a pandemic
  publication-title: Acta Biomed
– volume: 76
  start-page: 2060
  year: 2020
  end-page: 2072
  ident: bb0070
  article-title: Registry of arterial and venous thromboembolic complications in patients with COVID‐19
  publication-title: J Am Coll Cardiol
– volume: 4
  start-page: 1178
  year: 2020
  end-page: 1191
  ident: bb0200
  article-title: Risk of venous thromboembolism in patients with COVID‐19: a systematic review and meta‐analysis
  publication-title: Res Pract Thromb Haemost.
– volume: 16
  year: 2021
  ident: bb0080
  article-title: Association of mortality and aspirin prescription for COVID‐19 patients at the veterans health administration
  publication-title: PLoS One
– reference: Gobierno de Mexico‐ IMSS. Calculadora de complicacion de salud por COVID‐19.
– reference: ACCF/AHA. Methodology Manual and Policies From the ACCF/AHA Task Force on Practice Guidelines.
– volume: 364
  start-page: 1305
  year: 2011
  end-page: 1314
  ident: bb0260
  article-title: Dalteparin versus unfractionated heparin in critically ill patients
  publication-title: N Engl J Med
– volume: 41
  year: 2021
  ident: bb0095
  article-title: Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID‐19 patients
  publication-title: EClinicalMedicine
– volume: 18
  start-page: 1859
  year: 2020
  end-page: 1865
  ident: bb0015
  article-title: Clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID‐19
  publication-title: J Thromb Haemost
– volume: 22
  start-page: 264
  year: 2021
  end-page: 271
  ident: bb0105
  article-title: Pre‐ and in‐hospital anticoagulation therapy in coronavirus disease 2019 patients: a propensity‐matched analysis of in‐hospital outcomes
  publication-title: J Cardiovasc Med (Hagerstown)
– volume: 52
  year: 2021
  ident: bb0170
  article-title: Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: the X‐COVID‐19 randomized trial
  publication-title: Eur J Clin Invest
– volume: 96
  start-page: 471
  year: 2021
  end-page: 479
  ident: bb0165
  article-title: Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: a propensity score‐matched analysis
  publication-title: Am J Hematol
– volume: 137
  start-page: 2838
  year: 2021
  end-page: 2847
  ident: bb0280
  article-title: Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID‐19: the CORE‐19 registry
  publication-title: Blood
– volume: 327
  start-page: 227
  year: 2022
  end-page: 236
  ident: bb0180
  article-title: Effect of P2Y12 inhibitors on survival free of organ support among non‐critically ill hospitalized patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
– volume: 52
  start-page: e364
  year: 2021
  end-page: e467
  ident: bb0305
  article-title: 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association
  publication-title: Stroke
– volume: 399
  start-page: 143
  year: 2022
  end-page: 151
  ident: bb0185
  article-title: Aspirin in patients admitted to hospital with COVID‐19 (RECOVERY): a randomised, controlled, open‐label, platform trial
  publication-title: Lancet
– year: 2022
  ident: bb0045
  article-title: Chapter 8: assessing risk of bias in a randomized trial
  publication-title: Cochrane Handbook for Systematic Reviews of Interventions Version 63 (Updated February 2022): Cochrane
– volume: 399
  start-page: 50
  year: 2022
  end-page: 59
  ident: bb0285
  article-title: Rivaroxaban versus no anticoagulation for post‐discharge thromboprophylaxis after hospitalisation for COVID‐19 (MICHELLE): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
– volume: 117
  start-page: 2807
  year: 2021
  end-page: 2820
  ident: bb0195
  article-title: Low‐molecular‐weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study
  publication-title: Cardiovasc Res
– volume: 20
  start-page: 2226
  year: 2022
  end-page: 2236
  ident: bb0025
  article-title: Good practice statements for antithrombotic therapy in the management of COVID‐19
  publication-title: J Thromb Haemost
– volume: 110
  start-page: 874
  year: 2004
  end-page: 879
  ident: bb0210
  article-title: Randomized, placebo‐controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
  publication-title: Circulation
– volume: 140
  start-page: 123
  year: 2022
  end-page: 133
  ident: bb0160
  article-title: Low molecular weight heparin is useful in adult COVID‐19 inpatients. Experience during the first Spanish wave: observational study
  publication-title: Sao Paulo Med J
– volume: 289
  start-page: 411
  year: 2021
  end-page: 419
  ident: bb0055
  article-title: Direct oral anticoagulant use and risk of severe COVID‐19
  publication-title: J Intern Med
– volume: 127
  start-page: 268
  year: 2013
  end-page: 310
  ident: bb0030
  article-title: ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines
  publication-title: Circulation
– reference: [accessed 2022, June 10].
– volume: 325
  start-page: 1620
  year: 2021
  end-page: 1630
  ident: bb0240
  article-title: Effect of intermediate‐dose vs standard‐dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID‐19 admitted to the intensive care unit: the INSPIRATION randomized clinical trial
  publication-title: JAMA
– reference: [accessed 2022, March 17].
– volume: 8
  start-page: 2450
  year: 2010
  end-page: 2457
  ident: bb0215
  article-title: A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua prediction score
  publication-title: J Thromb Haemost
– volume: 17
  start-page: 1013
  year: 2022
  end-page: 1021
  ident: bb0135
  article-title: Low in‐hospital mortality rate in patients with COVID‐19 receiving thromboprophylaxis: data from the multicentre observational START‐COVID register
  publication-title: Intern Emerg Med
– volume: 326
  start-page: 1703
  year: 2021
  end-page: 1712
  ident: bb0050
  article-title: Effect of antithrombotic therapy on clinical outcomes in outpatients with clinically stable symptomatic COVID‐19: the ACTIV‐4B randomized clinical trial
  publication-title: JAMA
– volume: 121
  start-page: 1043
  year: 2021
  end-page: 1053
  ident: bb0110
  article-title: Prevalence and predictors of venous thromboembolism or mortality in hospitalized COVID‐19 patients
  publication-title: Thromb Haemost
– volume: 75
  start-page: 3140
  year: 2020
  end-page: 3147
  ident: bb0295
  article-title: Post‐discharge prophylaxis with rivaroxaban reduces fatal and major thromboembolic events in medically ill patients
  publication-title: J Am Coll Cardiol
– volume: 1
  start-page: e56
  year: 2017
  end-page: e65
  ident: bb0225
  article-title: The IMPROVEDD VTE risk score: incorporation of D‐dimer into the IMPROVE score to improve venous thromboembolism risk stratification
  publication-title: TH Open
– volume: 11
  start-page: 1032
  year: 2021
  ident: bb0250
  article-title: Comparison of the effect of unfractionated heparin and enoxaparin sodium at different doses on the course of COVID‐19‐associated coagulopathy
  publication-title: Life (Basel)
– volume: 13
  start-page: 2119
  year: 2015
  end-page: 2126
  ident: bb0075
  article-title: Definition of clinically relevant non‐major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH
  publication-title: J Thromb Haemost
– volume: 185
  year: 2022
  ident: bb0290
  article-title: A prospective study of the impact of glycaemic status on clinical outcomes and anti‐SARS‐CoV‐2 antibody responses among patients with predominantly non‐severe COVID‐19
  publication-title: Diabetes Res Clin Pract
– volume: 3
  start-page: 692
  year: 2005
  end-page: 694
  ident: bb0275
  article-title: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients
  publication-title: J Thromb Haemost
– volume: 122
  start-page: 131
  year: 2021
  end-page: 141
  ident: bb0230
  article-title: Intermediate‐dose versus standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted to the iIntensive care unit: 90‐day results from the INSPIRATION randomized trial
  publication-title: Thromb Haemost
– year: 2022
  ident: bb0085
  article-title: Chronic anticoagulant treatment and risk of mortality in SARS‐Cov2 patients: a large population‐based study
  publication-title: Minerva Med
– volume: 76
  start-page: 2060
  year: 2020
  end-page: 2072
  article-title: Registry of arterial and venous thromboembolic complications in patients with COVID‐19
  publication-title: J Am Coll Cardiol
– volume: 16
  year: 2021
  article-title: Association of mortality and aspirin prescription for COVID‐19 patients at the veterans health administration
  publication-title: PLoS One
– volume: 17
  start-page: 1013
  issue: 4
  year: 2022
  end-page: 1021
  article-title: Low in‐hospital mortality rate in patients with COVID‐19 receiving thromboprophylaxis: data from the multicentre observational START‐COVID register
  publication-title: Intern Emerg Med
– volume: 18
  start-page: 1859
  year: 2020
  end-page: 1865
  article-title: Clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID‐19
  publication-title: J Thromb Haemost
– volume: 1
  start-page: e56
  year: 2017
  end-page: e65
  article-title: The IMPROVEDD VTE risk score: incorporation of D‐dimer into the IMPROVE score to improve venous thromboembolism risk stratification
  publication-title: TH Open
– volume: 19
  start-page: 2225
  year: 2021
  end-page: 2234
  article-title: Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID‐19: a multi‐center, open‐label, randomized controlled trial
  publication-title: J Thromb Haemost
– volume: 18
  start-page: 1023
  year: 2020
  end-page: 1026
  article-title: ISTH interim guidance on recognition and management of coagulopathy in COVID‐19
  publication-title: J Thromb Haemost
– volume: 22
  start-page: 264
  year: 2021
  end-page: 271
  article-title: Pre‐ and in‐hospital anticoagulation therapy in coronavirus disease 2019 patients: a propensity‐matched analysis of in‐hospital outcomes
  publication-title: J Cardiovasc Med (Hagerstown)
– volume: 181
  start-page: 1612
  year: 2021
  end-page: 1620
  article-title: Efficacy and safety of therapeutic‐dose heparin vs standard prophylactic or intermediate‐dose heparins for thromboprophylaxis in high‐risk hospitalized patients with COVID‐19: the HEP‐COVID randomized clinical trial
  publication-title: JAMA Intern Med
– volume: 211
  start-page: 114
  year: 2022
  end-page: 122
  article-title: The association between anticoagulation and adverse outcomes after a positive SARS‐CoV‐2 test among older outpatients: a population‐based cohort study
  publication-title: Thromb Res
– volume: 4
  start-page: 915
  year: 2006
  end-page: 916
  article-title: Identifying acutely ill medical patients requiring thromboprophylaxis
  publication-title: J Thromb Haemost
– volume: 140
  start-page: 123
  year: 2022
  end-page: 133
  article-title: Low molecular weight heparin is useful in adult COVID‐19 inpatients. Experience during the first Spanish wave: observational study
  publication-title: Sao Paulo Med J
– volume: 327
  start-page: 1247
  year: 2022
  end-page: 1259
  article-title: Effect of antiplatelet therapy on survival and organ support‐free days in critically ill patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
– volume: 289
  start-page: 411
  year: 2021
  end-page: 419
  article-title: Direct oral anticoagulant use and risk of severe COVID‐19
  publication-title: J Intern Med
– volume: 4
  start-page: 1178
  year: 2020
  end-page: 1191
  article-title: Risk of venous thromboembolism in patients with COVID‐19: a systematic review and meta‐analysis
  publication-title: Res Pract Thromb Haemost.
– volume: 8
  start-page: 2450
  year: 2010
  end-page: 2457
  article-title: A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua prediction score
  publication-title: J Thromb Haemost
– volume: 196
  start-page: 359
  year: 2020
  end-page: 366
  article-title: Therapeutic versus prophylactic anticoagulation for severe COVID‐19: a randomized phase II clinical trial (HESACOVID)
  publication-title: Thromb Res
– volume: 5
  year: 2021
  article-title: Randomized trials of therapeutic heparin for COVID‐19: a meta‐analysis
  publication-title: Res Pract Thromb Haemost
– volume: 52
  year: 2021
  article-title: Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: the X‐COVID‐19 randomized trial
  publication-title: Eur J Clin Invest
– volume: 8
  year: 2021
  article-title: Intermediate‐ vs. standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted in medical Ward: a propensity score‐matched cohort study
  publication-title: Front Med (Lausanne)
– volume: 52
  start-page: e364
  year: 2021
  end-page: e467
  article-title: 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association
  publication-title: Stroke
– year: 2022
– volume: 385
  start-page: 790
  year: 2021
  end-page: 802
  article-title: Therapeutic anticoagulation with heparin in noncritically ill patients with Covid‐19
  publication-title: N Engl J Med
– volume: 41
  year: 2021
  article-title: Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID‐19 patients
  publication-title: EClinicalMedicine
– volume: 121
  start-page: 1043
  year: 2021
  end-page: 1053
  article-title: Prevalence and predictors of venous thromboembolism or mortality in hospitalized COVID‐19 patients
  publication-title: Thromb Haemost
– volume: 96
  start-page: 471
  year: 2021
  end-page: 479
  article-title: Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: a propensity score‐matched analysis
  publication-title: Am J Hematol
– volume: 341
  start-page: 793
  year: 1999
  end-page: 800
  article-title: A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in medical patients with enoxaparin study group
  publication-title: N Engl J Med
– volume: 127
  start-page: 268
  year: 2013
  end-page: 310
  article-title: ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines
  publication-title: Circulation
– volume: 122
  start-page: 131
  year: 2021
  end-page: 141
  article-title: Intermediate‐dose versus standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted to the iIntensive care unit: 90‐day results from the INSPIRATION randomized trial
  publication-title: Thromb Haemost
– volume: 106
  start-page: 165
  year: 2021
  end-page: 174
  article-title: Association of anticoagulation dose and survival in hospitalized COVID‐19 patients: a retrospective propensity score‐weighted analysis
  publication-title: Eur J Haematol
– volume: 397
  start-page: 2253
  year: 2021
  end-page: 2263
  article-title: Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID‐19 and elevated D‐dimer concentration (ACTION): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
– volume: 110
  start-page: 874
  year: 2004
  end-page: 879
  article-title: Randomized, placebo‐controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
  publication-title: Circulation
– volume: 2
  start-page: 3198
  year: 2018
  end-page: 3225
  article-title: American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients
  publication-title: Blood Adv
– volume: 185
  year: 2022
  article-title: A prospective study of the impact of glycaemic status on clinical outcomes and anti‐SARS‐CoV‐2 antibody responses among patients with predominantly non‐severe COVID‐19
  publication-title: Diabetes Res Clin Pract
– volume: 20
  start-page: 2226
  year: 2022
  end-page: 2236
  article-title: Good practice statements for antithrombotic therapy in the management of COVID‐19
  publication-title: J Thromb Haemost
– volume: 11
  start-page: 1032
  year: 2021
  article-title: Comparison of the effect of unfractionated heparin and enoxaparin sodium at different doses on the course of COVID‐19‐associated coagulopathy
  publication-title: Life (Basel)
– volume: 372
  year: 2021
  article-title: Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
  publication-title: BMJ
– volume: 13
  start-page: 2119
  year: 2015
  end-page: 2126
  article-title: Definition of clinically relevant non‐major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH
  publication-title: J Thromb Haemost
– volume: 399
  start-page: 50
  year: 2022
  end-page: 59
  article-title: Rivaroxaban versus no anticoagulation for post‐discharge thromboprophylaxis after hospitalisation for COVID‐19 (MICHELLE): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
– volume: 14
  start-page: 172
  year: 2021
  article-title: Association between warfarin and COVID‐19‐related outcomes compared with direct oral anticoagulants: population‐based cohort study
  publication-title: J Hematol Oncol
– volume: 325
  start-page: 1620
  year: 2021
  end-page: 1630
  article-title: Effect of intermediate‐dose vs standard‐dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID‐19 admitted to the intensive care unit: the INSPIRATION randomized clinical trial
  publication-title: JAMA
– volume: 3
  start-page: 692
  year: 2005
  end-page: 694
  article-title: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients
  publication-title: J Thromb Haemost
– volume: 121
  start-page: 1054
  year: 2021
  end-page: 1065
  article-title: Heparin in COVID‐19 patients is associated with reduced in‐hospital mortality: the multicenter Italian CORIST study
  publication-title: Thromb Haemost
– volume: 385
  start-page: 777
  year: 2021
  end-page: 789
  article-title: Therapeutic anticoagulation with heparin in critically ill patients with Covid‐19
  publication-title: N Engl J Med
– volume: 327
  start-page: 227
  year: 2022
  end-page: 236
  article-title: Effect of P2Y12 inhibitors on survival free of organ support among non‐critically ill hospitalized patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
– volume: 117
  start-page: 2807
  year: 2021
  end-page: 2820
  article-title: Low‐molecular‐weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study
  publication-title: Cardiovasc Res
– volume: 121
  start-page: 944
  year: 2021
  end-page: 954
  article-title: Sulodexide in the treatment of patients with early stages of COVID‐19: a randomized controlled trial
  publication-title: Thromb Haemost
– year: 2022
  article-title: Chronic anticoagulant treatment and risk of mortality in SARS‐Cov2 patients: a large population‐based study
  publication-title: Minerva Med
– volume: 364
  start-page: 1305
  year: 2011
  end-page: 1314
  article-title: Dalteparin versus unfractionated heparin in critically ill patients
  publication-title: N Engl J Med
– volume: 137
  start-page: 2838
  year: 2021
  end-page: 2847
  article-title: Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID‐19: the CORE‐19 registry
  publication-title: Blood
– volume: 399
  start-page: 143
  year: 2022
  end-page: 151
  article-title: Aspirin in patients admitted to hospital with COVID‐19 (RECOVERY): a randomised, controlled, open‐label, platform trial
  publication-title: Lancet
– volume: 75
  start-page: 3140
  year: 2020
  end-page: 3147
  article-title: Post‐discharge prophylaxis with rivaroxaban reduces fatal and major thromboembolic events in medically ill patients
  publication-title: J Am Coll Cardiol
– volume: 375
  year: 2021
  article-title: Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid‐19 admitted to hospital: RAPID randomised clinical trial
  publication-title: BMJ
– volume: 91
  start-page: 157
  year: 2020
  end-page: 160
  article-title: WHO declares COVID‐19 a pandemic
  publication-title: Acta Biomed
– volume: 36
  start-page: 113
  year: 2021
  end-page: 120
  article-title: The association of low molecular weight heparin use and in‐hospital mortality among patients hospitalized with COVID‐19
  publication-title: Cardiovasc Drugs Ther
– volume: 205
  start-page: 1
  year: 2021
  end-page: 7
  article-title: Direct‐acting oral anticoagulants use prior to COVID‐19 diagnosis and associations with 30‐day clinical outcomes
  publication-title: Thromb Res
– volume: 326
  start-page: 1703
  year: 2021
  end-page: 1712
  article-title: Effect of antithrombotic therapy on clinical outcomes in outpatients with clinically stable symptomatic COVID‐19: the ACTIV‐4B randomized clinical trial
  publication-title: JAMA
– ident: 10.1111/jth.15808_bb0040
– volume: 325
  start-page: 1620
  year: 2021
  ident: 10.1111/jth.15808_bb0240
  publication-title: JAMA
  doi: 10.1001/jama.2021.4152
– volume: 375
  year: 2021
  ident: 10.1111/jth.15808_bb0140
  article-title: Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid‐19 admitted to hospital: RAPID randomised clinical trial
  publication-title: BMJ
– volume: 18
  start-page: 1859
  year: 2020
  ident: 10.1111/jth.15808_bb0015
  article-title: Clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID‐19
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.14929
– volume: 121
  start-page: 1043
  year: 2021
  ident: 10.1111/jth.15808_bb0110
  article-title: Prevalence and predictors of venous thromboembolism or mortality in hospitalized COVID‐19 patients
  publication-title: Thromb Haemost
  doi: 10.1055/a-1366-9656
– volume: 399
  start-page: 143
  year: 2022
  ident: 10.1111/jth.15808_bb0185
  article-title: Aspirin in patients admitted to hospital with COVID‐19 (RECOVERY): a randomised, controlled, open‐label, platform trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01825-0
– volume: 8
  start-page: 2450
  year: 2010
  ident: 10.1111/jth.15808_bb0215
  article-title: A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua prediction score
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2010.04044.x
– volume: 289
  start-page: 411
  year: 2021
  ident: 10.1111/jth.15808_bb0055
  article-title: Direct oral anticoagulant use and risk of severe COVID‐19
  publication-title: J Intern Med
  doi: 10.1111/joim.13205
– volume: 5
  year: 2021
  ident: 10.1111/jth.15808_bb0155
  article-title: Randomized trials of therapeutic heparin for COVID‐19: a meta‐analysis
  publication-title: Res Pract Thromb Haemost
  doi: 10.1002/rth2.12638
– volume: 399
  start-page: 50
  year: 2022
  ident: 10.1111/jth.15808_bb0285
  article-title: Rivaroxaban versus no anticoagulation for post‐discharge thromboprophylaxis after hospitalisation for COVID‐19 (MICHELLE): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)02392-8
– volume: 372
  year: 2021
  ident: 10.1111/jth.15808_bb0125
  article-title: Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
  publication-title: BMJ
– volume: 22
  start-page: 264
  year: 2021
  ident: 10.1111/jth.15808_bb0105
  article-title: Pre‐ and in‐hospital anticoagulation therapy in coronavirus disease 2019 patients: a propensity‐matched analysis of in‐hospital outcomes
  publication-title: J Cardiovasc Med (Hagerstown)
– volume: 91
  start-page: 157
  year: 2020
  ident: 10.1111/jth.15808_bb0010
  article-title: WHO declares COVID‐19 a pandemic
  publication-title: Acta Biomed
– volume: 185
  year: 2022
  ident: 10.1111/jth.15808_bb0290
  article-title: A prospective study of the impact of glycaemic status on clinical outcomes and anti‐SARS‐CoV‐2 antibody responses among patients with predominantly non‐severe COVID‐19
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2022.109232
– ident: 10.1111/jth.15808_bb0100
– year: 2022
  ident: 10.1111/jth.15808_bb0045
  article-title: Chapter 8: assessing risk of bias in a randomized trial
– volume: 41
  year: 2021
  ident: 10.1111/jth.15808_bb0095
  article-title: Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID‐19 patients
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2021.101139
– volume: 16
  year: 2021
  ident: 10.1111/jth.15808_bb0080
  article-title: Association of mortality and aspirin prescription for COVID‐19 patients at the veterans health administration
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0246825
– volume: 117
  start-page: 2807
  year: 2021
  ident: 10.1111/jth.15808_bb0195
  article-title: Low‐molecular‐weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvab308
– volume: 137
  start-page: 2838
  year: 2021
  ident: 10.1111/jth.15808_bb0280
  article-title: Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID‐19: the CORE‐19 registry
  publication-title: Blood
  doi: 10.1182/blood.2020010529
– volume: 122
  start-page: 131
  year: 2021
  ident: 10.1111/jth.15808_bb0230
  article-title: Intermediate‐dose versus standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted to the iIntensive care unit: 90‐day results from the INSPIRATION randomized trial
  publication-title: Thromb Haemost
  doi: 10.1055/a-1485-2372
– volume: 121
  start-page: 944
  year: 2021
  ident: 10.1111/jth.15808_bb0065
  article-title: Sulodexide in the treatment of patients with early stages of COVID‐19: a randomized controlled trial
  publication-title: Thromb Haemost
  doi: 10.1055/a-1414-5216
– volume: 364
  start-page: 1305
  year: 2011
  ident: 10.1111/jth.15808_bb0260
  article-title: Dalteparin versus unfractionated heparin in critically ill patients
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1014475
– volume: 13
  start-page: 2119
  year: 2015
  ident: 10.1111/jth.15808_bb0075
  article-title: Definition of clinically relevant non‐major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.13140
– volume: 4
  start-page: 915
  year: 2006
  ident: 10.1111/jth.15808_bb0220
  article-title: Identifying acutely ill medical patients requiring thromboprophylaxis
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2006.01818.x
– volume: 326
  start-page: 1703
  year: 2021
  ident: 10.1111/jth.15808_bb0050
  article-title: Effect of antithrombotic therapy on clinical outcomes in outpatients with clinically stable symptomatic COVID‐19: the ACTIV‐4B randomized clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.2021.17272
– volume: 327
  start-page: 1247
  year: 2022
  ident: 10.1111/jth.15808_bb0255
  article-title: Effect of antiplatelet therapy on survival and organ support‐free days in critically ill patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
  doi: 10.1001/jama.2022.2910
– volume: 327
  start-page: 227
  year: 2022
  ident: 10.1111/jth.15808_bb0180
  article-title: Effect of P2Y12 inhibitors on survival free of organ support among non‐critically ill hospitalized patients with COVID‐19: a randomized clinical trial
  publication-title: Jama
  doi: 10.1001/jama.2021.23605
– volume: 385
  start-page: 777
  year: 2021
  ident: 10.1111/jth.15808_bb0245
  article-title: Therapeutic anticoagulation with heparin in critically ill patients with Covid‐19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2103417
– volume: 205
  start-page: 1
  year: 2021
  ident: 10.1111/jth.15808_bb0060
  article-title: Direct‐acting oral anticoagulants use prior to COVID‐19 diagnosis and associations with 30‐day clinical outcomes
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2021.06.014
– volume: 8
  year: 2021
  ident: 10.1111/jth.15808_bb0175
  article-title: Intermediate‐ vs. standard‐dose prophylactic anticoagulation in patients with COVID‐19 admitted in medical Ward: a propensity score‐matched cohort study
  publication-title: Front Med (Lausanne)
– volume: 385
  start-page: 790
  year: 2021
  ident: 10.1111/jth.15808_bb0150
  article-title: Therapeutic anticoagulation with heparin in noncritically ill patients with Covid‐19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2105911
– volume: 14
  start-page: 172
  year: 2021
  ident: 10.1111/jth.15808_bb0300
  article-title: Association between warfarin and COVID‐19‐related outcomes compared with direct oral anticoagulants: population‐based cohort study
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-021-01185-0
– volume: 19
  start-page: 2225
  year: 2021
  ident: 10.1111/jth.15808_bb0235
  article-title: Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID‐19: a multi‐center, open‐label, randomized controlled trial
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.15450
– volume: 11
  start-page: 1032
  year: 2021
  ident: 10.1111/jth.15808_bb0250
  article-title: Comparison of the effect of unfractionated heparin and enoxaparin sodium at different doses on the course of COVID‐19‐associated coagulopathy
  publication-title: Life (Basel)
– volume: 20
  start-page: 2226
  year: 2022
  ident: 10.1111/jth.15808_bb0025
  article-title: Good practice statements for antithrombotic therapy in the management of COVID‐19
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.15809
– volume: 52
  year: 2021
  ident: 10.1111/jth.15808_bb0170
  article-title: Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: the X‐COVID‐19 randomized trial
  publication-title: Eur J Clin Invest
– volume: 121
  start-page: 1054
  year: 2021
  ident: 10.1111/jth.15808_bb0115
  article-title: Heparin in COVID‐19 patients is associated with reduced in‐hospital mortality: the multicenter Italian CORIST study
  publication-title: Thromb Haemost
  doi: 10.1055/a-1347-6070
– volume: 397
  start-page: 2253
  year: 2021
  ident: 10.1111/jth.15808_bb0190
  article-title: Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID‐19 and elevated D‐dimer concentration (ACTION): an open‐label, multicentre, randomised, controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01203-4
– volume: 196
  start-page: 359
  year: 2020
  ident: 10.1111/jth.15808_bb0270
  article-title: Therapeutic versus prophylactic anticoagulation for severe COVID‐19: a randomized phase II clinical trial (HESACOVID)
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2020.09.026
– volume: 211
  start-page: 114
  year: 2022
  ident: 10.1111/jth.15808_bb0090
  article-title: The association between anticoagulation and adverse outcomes after a positive SARS‐CoV‐2 test among older outpatients: a population‐based cohort study
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2021.12.010
– volume: 127
  start-page: 268
  year: 2013
  ident: 10.1111/jth.15808_bb0030
  article-title: ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines
  publication-title: Circulation
  doi: 10.1161/CIR.0b013e31827e8e5f
– volume: 76
  start-page: 2060
  year: 2020
  ident: 10.1111/jth.15808_bb0070
  article-title: Registry of arterial and venous thromboembolic complications in patients with COVID‐19
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2020.08.070
– volume: 36
  start-page: 113
  year: 2021
  ident: 10.1111/jth.15808_bb0130
  article-title: The association of low molecular weight heparin use and in‐hospital mortality among patients hospitalized with COVID‐19
  publication-title: Cardiovasc Drugs Ther
  doi: 10.1007/s10557-020-07133-3
– volume: 110
  start-page: 874
  year: 2004
  ident: 10.1111/jth.15808_bb0210
  article-title: Randomized, placebo‐controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000138928.83266.24
– volume: 96
  start-page: 471
  year: 2021
  ident: 10.1111/jth.15808_bb0165
  article-title: Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: a propensity score‐matched analysis
  publication-title: Am J Hematol
  doi: 10.1002/ajh.26102
– volume: 140
  start-page: 123
  year: 2022
  ident: 10.1111/jth.15808_bb0160
  article-title: Low molecular weight heparin is useful in adult COVID‐19 inpatients. Experience during the first Spanish wave: observational study
  publication-title: Sao Paulo Med J
  doi: 10.1590/1516-3180.2021.0098.r1.08062021
– ident: 10.1111/jth.15808_bb0035
– volume: 106
  start-page: 165
  year: 2021
  ident: 10.1111/jth.15808_bb0120
  article-title: Association of anticoagulation dose and survival in hospitalized COVID‐19 patients: a retrospective propensity score‐weighted analysis
  publication-title: Eur J Haematol
  doi: 10.1111/ejh.13533
– volume: 181
  start-page: 1612
  year: 2021
  ident: 10.1111/jth.15808_bb0145
  article-title: Efficacy and safety of therapeutic‐dose heparin vs standard prophylactic or intermediate‐dose heparins for thromboprophylaxis in high‐risk hospitalized patients with COVID‐19: the HEP‐COVID randomized clinical trial
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2021.6203
– volume: 3
  start-page: 692
  year: 2005
  ident: 10.1111/jth.15808_bb0275
  article-title: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2005.01204.x
– volume: 17
  start-page: 1013
  issue: 4
  year: 2022
  ident: 10.1111/jth.15808_bb0135
  article-title: Low in‐hospital mortality rate in patients with COVID‐19 receiving thromboprophylaxis: data from the multicentre observational START‐COVID register
  publication-title: Intern Emerg Med
  doi: 10.1007/s11739-021-02891-w
– volume: 4
  start-page: 1178
  year: 2020
  ident: 10.1111/jth.15808_bb0200
  article-title: Risk of venous thromboembolism in patients with COVID‐19: a systematic review and meta‐analysis
  publication-title: Res Pract Thromb Haemost.
  doi: 10.1002/rth2.12439
– volume: 341
  start-page: 793
  year: 1999
  ident: 10.1111/jth.15808_bb0205
  article-title: A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in medical patients with enoxaparin study group
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199909093411103
– volume: 2
  start-page: 3198
  year: 2018
  ident: 10.1111/jth.15808_bb0265
  article-title: American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2018022954
– volume: 18
  start-page: 1023
  year: 2020
  ident: 10.1111/jth.15808_bb0020
  article-title: ISTH interim guidance on recognition and management of coagulopathy in COVID‐19
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.14810
– year: 2022
  ident: 10.1111/jth.15808_bb0085
  article-title: Chronic anticoagulant treatment and risk of mortality in SARS‐Cov2 patients: a large population‐based study
  publication-title: Minerva Med
– volume: 1
  start-page: e56
  year: 2017
  ident: 10.1111/jth.15808_bb0225
  article-title: The IMPROVEDD VTE risk score: incorporation of D‐dimer into the IMPROVE score to improve venous thromboembolism risk stratification
  publication-title: TH Open
  doi: 10.1055/s-0037-1603929
– volume: 52
  start-page: e364
  year: 2021
  ident: 10.1111/jth.15808_bb0305
  article-title: 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association
  publication-title: Stroke
  doi: 10.1161/STR.0000000000000375
– volume: 75
  start-page: 3140
  year: 2020
  ident: 10.1111/jth.15808_bb0295
  article-title: Post‐discharge prophylaxis with rivaroxaban reduces fatal and major thromboembolic events in medically ill patients
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2020.04.071
– reference: 36271456 - J Thromb Haemost. 2022 Nov;20(11):2708-2709. doi: 10.1111/jth.15855
– reference: 36271457 - J Thromb Haemost. 2022 Nov;20(11):2710-2711. doi: 10.1111/jth.15854
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Snippet Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID‐19) may realize additional...
Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID-19) may realize additional...
SourceID pubmedcentral
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pubmed
crossref
wiley
elsevier
SourceType Open Access Repository
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StartPage 2214
SubjectTerms Aftercare
anticoagulants
Anticoagulants - adverse effects
Coronaviruses
COVID-19
critical illness
Dosage
Fibrinolytic Agents - adverse effects
Heparin
Heparin - adverse effects
Heparin, Low-Molecular-Weight
Hospitalization
Humans
Molecular weight
Patient Discharge
Patients
platelet aggregation inhibitors
Platelet Aggregation Inhibitors - adverse effects
Recommendations and Guidelines
Rivaroxaban
Thromboembolism
Title ISTH guidelines for antithrombotic treatment in COVID‐19
URI https://dx.doi.org/10.1111/jth.15808
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjth.15808
https://www.ncbi.nlm.nih.gov/pubmed/35906716
https://www.proquest.com/docview/2715607376
https://www.proquest.com/docview/2696858634
https://pubmed.ncbi.nlm.nih.gov/PMC9349907
Volume 20
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