Spatial control of nucleoporin condensation by fragile X‐related proteins

Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve‐like hydrogel within the central channel of the NPCs. In the cytoplasm, the soluble Nups exist, but how their assembly is restricted to the NE is currently unknow...

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Veröffentlicht in:	The EMBO journal Jg. 39; H. 20; S. e104467 - n/a
Hauptverfasser:	Agote‐Aran, Arantxa, Schmucker, Stephane, Jerabkova, Katerina, Jmel Boyer, Inès, Berto, Alessandro, Pacini, Laura, Ronchi, Paolo, Kleiss, Charlotte, Guerard, Laurent, Schwab, Yannick, Moine, Hervé, Mandel, Jean‐Louis, Jacquemont, Sebastien, Bagni, Claudia, Sumara, Izabela
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 15.10.2020 Springer Nature B.V EMBO Press John Wiley and Sons Inc
Schlagworte:	Acrylates - pharmacology Animals Cell cycle Cell Line Cell morphology Cell Nucleus - metabolism Condensates Condensation Cytology Cytoplasm Cytoplasm - drug effects Cytoplasm - metabolism Down-Regulation Dynein EMBO20 FMR1 protein Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X syndrome Fragile X Syndrome - genetics Fragile X Syndrome - metabolism FXR1 G1 phase G1 Phase Cell Cycle Checkpoints - genetics Granular materials Humans Hydrogels In Situ Hybridization, Fluorescence Intellectual disabilities Interphase - genetics Life Sciences Localization Mice Microscopy, Electron, Transmission Microtubules - drug effects Microtubules - metabolism Microtubules - ultrastructure Morphology Myoblasts - drug effects Myoblasts - metabolism Nuclear Envelope - drug effects Nuclear Envelope - metabolism Nuclear Envelope - ultrastructure Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Nucleoporins Phase separation Protein transport Proteins RNA, Small Interfering RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism dynein FXR1 phase separation nucleoporins fragile X syndrome phase separation Subject Category Membrane & Trafficking
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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