Advances and challenges in drug design against dental caries: Application of in silico approaches

Dental caries, a chronic disease characterized by tooth decay, occupies the second position in terms of disease burden and is primarily caused by cariogenic bacteria, especially Streptococcus mutans, because of its acidogenic, aciduric, and biofilm-forming capabilities. Developing novel targeted ant...

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Bibliographic Details
Published in:	Journal of pharmaceutical analysis Vol. 15; no. 6; pp. 101161 - 13
Main Authors:	Chen, Zhongxin, Zhao, Xinyao, Zheng, Hanyu, Wang, Yufei, Zhang, Linglin
Format:	Journal Article
Language:	English
Published:	China Elsevier B.V 01.06.2025 Xi'an Jiaotong University, Journal of Pharmaceutical Analysis Xi'an Jiaotong University Elsevier
Subjects:	Acids Adenosine triphosphatase AI-Assisted drug design Antigen I/II Antigens Bacteria Biofilms Biological activity Chronic illnesses Computer-aided drug design Dental caries Drug delivery Drug development Fluorides Glucosyltransferases Ligands Metabolism Oxidative stress Review Paper Signal transduction Sortase Sortase A Streptococcus mutans Virulence Dental caries Sortase A Computer-aided drug design Antigen I/II Glucosyltransferases Streptococcus mutans AI-Assisted drug design
ISSN:	2095-1779, 2214-0883, 2214-0883
Online Access:	Get full text
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