WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy

The classical X shape of mitotic human chromosomes is the consequence of two distinct waves of cohesin removal. First, during prophase and prometaphase, the bulk of cohesin is driven from chromosome arms by the cohesin antagonist WAPL. This arm-specific cohesin removal is referred to as the prophase...

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Bibliographic Details
Published in:	Current biology Vol. 23; no. 20; p. 2071
Main Authors:	Haarhuis, Judith H I, Elbatsh, Ahmed M O, van den Broek, Bram, Camps, Daniel, Erkan, Hasan, Jalink, Kees, Medema, René H, Rowland, Benjamin D
Format:	Journal Article
Language:	English
Published:	England 21.10.2013
Subjects:	Aneuploidy Aurora Kinase B - genetics Aurora Kinase B - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Centromere - metabolism Chromatids - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation Chromosomes, Human - metabolism Cohesins Humans Microscopy, Phase-Contrast Nuclear Proteins - genetics Nuclear Proteins - metabolism Prophase Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Retinal Pigment Epithelium
ISSN:	1879-0445, 1879-0445
Online Access:	Get more information
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