Targeting autophagy in cancer

Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting t...

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Vydáno v:Cancer Ročník 124; číslo 16; s. 3307 - 3318
Hlavní autoři: Onorati, Angelique V., Dyczynski, Matheus, Ojha, Rani, Amaravadi, Ravi K.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 01.08.2018
Témata:
Autophagy
Autophagy - drug effects
Autophagy - genetics
Cancer
Carcinogenesis - drug effects
Carcinogenesis - genetics
chemotherapy
Clinical trials
Drug Development
Homeostasis
Humans
Hydroxychloroquine
hydroxychloroquine (HCQ)
Immunity
Immunotherapy
Literature reviews
Medical research
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - epidemiology
Neoplasms - genetics
Oncology
Phagocytosis
Tumors
hydroxychloroquine (HCQ)
Autophagy
chemotherapy
immunotherapy
ISSN:0008-543X, 1097-0142, 1097-0142
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Shrnutí:Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. Early results from clinical trials that repurposed hydroxychloroquine for cancer have suggested that autophagy inhibition may be a promising approach for advanced cancers. In this review of the literature, the authors present fundamental advances in the biology of autophagy, approaches to targeting autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role of autophagy in tumor immunity, and recent developments in next‐generation autophagy inhibitors that have clinical potential. Autophagy is a promising target for drug development in cancer. Cancer 2018. © 2018 American Cancer Society. Autophagy is an emerging target in cancer therapy. This review highlights recent advances in basic understanding of autophagy, results from clinical trials targeting autophagy, and future directions for the field.
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ISSN:0008-543X
1097-0142
1097-0142
DOI:10.1002/cncr.31335