Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

Naive CD4 T lymphocytes differentiate into different effector types, including helper and regulatory cells (Th and Treg, respectively). Heritable gene expression programs that define these effector types are established during differentiation, but little is known about the epigenetic mechanisms that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 51; S. 25839
Hauptverfasser:	Gehrmann, Ulf, Burbage, Marianne, Zueva, Elina, Goudot, Christel, Esnault, Cyril, Ye, Mengliang, Carpier, Jean-Marie, Burgdorf, Nina, Hoyler, Thomas, Suarez, Guadalupe, Joannas, Leonel, Heurtebise-Chrétien, Sandrine, Durand, Sylvère, Panes, Rébecca, Bellemare-Pelletier, Angélique, Sáez, Pablo J, Aprahamian, Fanny, Lefevre, Deborah, Adoue, Veronique, Zine El Aabidine, Amal, Muhammad Ahmad, Maqbool, Hivroz, Claire, Joffre, Olivier, Cammas, Florence, Kroemer, Guido, Gagnon, Etienne, Andrau, Jean-Christophe, Amigorena, Sebastian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.12.2019
Schlagworte:	Animals Autoimmunity - physiology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - physiology Cell Plasticity - physiology Cellular Reprogramming - genetics Cellular Reprogramming - physiology Chromosomal Proteins, Non-Histone - metabolism Colon - pathology Cytokines - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic - physiology Gene Expression Regulation Gene Silencing Histones - metabolism Mice Mice, Knockout Phosphatidylinositol 3-Kinases - metabolism Receptors, Antigen, T-Cell - metabolism T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transcriptome Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism TRIM28 autoimmunity T cells immunology epigenetics
ISSN:	1091-6490, 1091-6490
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