The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies

Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in...

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Published in:	Aging and disease Vol. 12; no. 8; pp. 1977 - 2002
Main Authors:	Liu, Xiaodan, Naomi, S. Sta Maria, Sharon, Wu Lin, Russell, E. Jacobs
Format:	Journal Article
Language:	English
Published:	United States JKL International 01.12.2021 JKL International LLC
Subjects:	Alzheimer's disease Care and treatment Diagnosis Diagnosis, Ultrasonic Review United States systematic review Focused ultrasound (FUS) Alzheimer’s disease (AD)
ISSN:	2152-5250, 2152-5250
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Abstract	Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization.
AbstractList	Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization.Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization. Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization. Key words: Focused ultrasound (FUS), Alzheimer's disease (AD), systematic review Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization.
Audience	Academic
Author	Russell, E. Jacobs Liu, Xiaodan Sharon, Wu Lin Naomi, S. Sta Maria
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Cites_doi	10.1016/j.brainresbull.2019.08.002 10.1016/j.neuroimage.2019.06.060 10.1016/j.ultrasmedbio.2016.05.004 10.1126/scitranslmed.aaa2512 10.1126/sciadv.aax6646 10.1007/s00401-016-1570-0 10.1186/1471-2288-14-43 10.1155/2013/616197 10.1111/febs.14332 10.1016/j.brs.2018.05.012 10.1002/jum.14256 10.1148/radiol.14140245 10.1016/j.brainres.2017.10.015 10.1038/s41598-018-32250-3 10.7150/ijms.36775 10.1016/j.neuroscience.2010.04.001 10.1016/j.cell.2015.10.067 10.1002/med.10004 10.1371/journal.pmed.1000097 10.4155/tde.10.66 10.1371/journal.pone.0125911 10.3389/fnins.2018.00055 10.1088/0031-9155/51/4/003 10.1259/bjr.20180601 10.1016/j.ultrasmedbio.2015.10.009 10.1016/j.redox.2017.10.014 10.1038/nrneurol.2017.188 10.1039/C9NR09713A 10.1002/cne.901850307 10.1166/jnn.2009.GR09 10.1586/14737175.2015.1028369 10.1016/j.jconrel.2015.02.027 10.1021/acsami.8b08230 10.1002/ana.25604 10.1016/j.jconrel.2014.07.051 10.1016/j.jphys.2019.08.005 10.3171/2017.11.FOCUS17627 10.1517/17425247.2014.897693 10.1038/s41467-018-04529-6 10.1016/j.neurobiolaging.2018.06.004 10.1016/j.brs.2011.03.007 10.1038/s41598-019-45577-2 10.1074/jbc.M110.147801 10.1016/j.brs.2019.07.024 10.1016/j.neuron.2014.12.032 10.7150/thno.36718 10.1016/j.ultrasmedbio.2004.04.010 10.1186/s13195-019-0569-x 10.1007/978-3-642-45106-5_5 10.1073/pnas.1908658117 10.1159/000490349 10.3389/fnmol.2014.00046 10.1002/alz.12068 10.1016/j.ultrasmedbio.2007.12.015 10.1093/brain/awx052 10.7150/thno.34388 10.1371/journal.pone.0002175 10.1084/jem.20171406 10.1016/j.trci.2019.06.007 10.1093/brain/awy132 10.2991/mseee-17.2017.36 10.1038/srep09671 10.1038/s41598-020-73151-8 10.1038/s41598-018-31071-8 10.1016/j.addr.2011.11.010 10.1371/journal.pone.0010549 10.7150/thno.28717 10.1016/j.brs.2020.03.016 10.1016/j.neuropharm.2016.02.014 10.1126/science.7046051 10.1016/j.jconrel.2010.10.038 10.1002/advs.201902583 10.1073/pnas.2002571117 10.1016/j.expneurol.2013.05.008 10.1038/jcbfm.2014.71 10.3389/fnins.2019.01350
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References	key-10.14336/AD.2021.0510-2 key-10.14336/AD.2021.0510-3 key-10.14336/AD.2021.0510-4 key-10.14336/AD.2021.0510-5 key-10.14336/AD.2021.0510-1 key-10.14336/AD.2021.0510-49 key-10.14336/AD.2021.0510-48 key-10.14336/AD.2021.0510-47 key-10.14336/AD.2021.0510-46 key-10.14336/AD.2021.0510-45 key-10.14336/AD.2021.0510-44 key-10.14336/AD.2021.0510-43 key-10.14336/AD.2021.0510-42 key-10.14336/AD.2021.0510-6 key-10.14336/AD.2021.0510-41 key-10.14336/AD.2021.0510-7 key-10.14336/AD.2021.0510-40 key-10.14336/AD.2021.0510-8 key-10.14336/AD.2021.0510-9 key-10.14336/AD.2021.0510-39 key-10.14336/AD.2021.0510-38 key-10.14336/AD.2021.0510-37 key-10.14336/AD.2021.0510-36 key-10.14336/AD.2021.0510-35 key-10.14336/AD.2021.0510-34 key-10.14336/AD.2021.0510-33 key-10.14336/AD.2021.0510-32 key-10.14336/AD.2021.0510-76 key-10.14336/AD.2021.0510-31 key-10.14336/AD.2021.0510-75 key-10.14336/AD.2021.0510-30 key-10.14336/AD.2021.0510-74 key-10.14336/AD.2021.0510-73 key-10.14336/AD.2021.0510-72 key-10.14336/AD.2021.0510-71 key-10.14336/AD.2021.0510-70 key-10.14336/AD.2021.0510-29 key-10.14336/AD.2021.0510-28 key-10.14336/AD.2021.0510-27 key-10.14336/AD.2021.0510-26 key-10.14336/AD.2021.0510-25 key-10.14336/AD.2021.0510-69 key-10.14336/AD.2021.0510-24 key-10.14336/AD.2021.0510-68 key-10.14336/AD.2021.0510-23 key-10.14336/AD.2021.0510-67 key-10.14336/AD.2021.0510-22 key-10.14336/AD.2021.0510-66 key-10.14336/AD.2021.0510-21 key-10.14336/AD.2021.0510-65 key-10.14336/AD.2021.0510-20 key-10.14336/AD.2021.0510-64 key-10.14336/AD.2021.0510-63 key-10.14336/AD.2021.0510-62 key-10.14336/AD.2021.0510-61 key-10.14336/AD.2021.0510-60 key-10.14336/AD.2021.0510-19 key-10.14336/AD.2021.0510-18 key-10.14336/AD.2021.0510-17 key-10.14336/AD.2021.0510-16 key-10.14336/AD.2021.0510-15 key-10.14336/AD.2021.0510-59 key-10.14336/AD.2021.0510-14 key-10.14336/AD.2021.0510-58 key-10.14336/AD.2021.0510-13 key-10.14336/AD.2021.0510-57 key-10.14336/AD.2021.0510-12 key-10.14336/AD.2021.0510-56 key-10.14336/AD.2021.0510-11 key-10.14336/AD.2021.0510-55 key-10.14336/AD.2021.0510-10 key-10.14336/AD.2021.0510-54 key-10.14336/AD.2021.0510-53 key-10.14336/AD.2021.0510-52 key-10.14336/AD.2021.0510-51 key-10.14336/AD.2021.0510-50
References_xml	– ident: key-10.14336/AD.2021.0510-37 doi: 10.1016/j.brainresbull.2019.08.002 – ident: key-10.14336/AD.2021.0510-39 doi: 10.1016/j.neuroimage.2019.06.060 – ident: key-10.14336/AD.2021.0510-59 doi: 10.1016/j.ultrasmedbio.2016.05.004 – ident: key-10.14336/AD.2021.0510-34 doi: 10.1126/scitranslmed.aaa2512 – ident: key-10.14336/AD.2021.0510-13 doi: 10.1126/sciadv.aax6646 – ident: key-10.14336/AD.2021.0510-68 doi: 10.1007/s00401-016-1570-0 – ident: key-10.14336/AD.2021.0510-30 doi: 10.1186/1471-2288-14-43 – ident: key-10.14336/AD.2021.0510-46 doi: 10.1155/2013/616197 – ident: key-10.14336/AD.2021.0510-57 doi: 10.1111/febs.14332 – ident: key-10.14336/AD.2021.0510-25 doi: 10.1016/j.brs.2018.05.012 – ident: key-10.14336/AD.2021.0510-6 doi: 10.1002/jum.14256 – ident: key-10.14336/AD.2021.0510-16 doi: 10.1148/radiol.14140245 – ident: key-10.14336/AD.2021.0510-8 doi: 10.1016/j.brainres.2017.10.015 – ident: key-10.14336/AD.2021.0510-18 doi: 10.1038/s41598-018-32250-3 – ident: key-10.14336/AD.2021.0510-72 doi: 10.7150/ijms.36775 – ident: key-10.14336/AD.2021.0510-61 doi: 10.1016/j.neuroscience.2010.04.001 – ident: key-10.14336/AD.2021.0510-75 doi: 10.1016/j.cell.2015.10.067 – ident: key-10.14336/AD.2021.0510-43 doi: 10.1002/med.10004 – ident: key-10.14336/AD.2021.0510-29 doi: 10.1371/journal.pmed.1000097 – ident: key-10.14336/AD.2021.0510-45 doi: 10.4155/tde.10.66 – ident: key-10.14336/AD.2021.0510-60 doi: 10.1371/journal.pone.0125911 – ident: key-10.14336/AD.2021.0510-17 doi: 10.3389/fnins.2018.00055 – ident: key-10.14336/AD.2021.0510-48 doi: 10.1088/0031-9155/51/4/003 – ident: key-10.14336/AD.2021.0510-49 doi: 10.1259/bjr.20180601 – ident: key-10.14336/AD.2021.0510-58 doi: 10.1016/j.ultrasmedbio.2015.10.009 – ident: key-10.14336/AD.2021.0510-56 doi: 10.1016/j.redox.2017.10.014 – ident: key-10.14336/AD.2021.0510-70 doi: 10.1038/nrneurol.2017.188 – ident: key-10.14336/AD.2021.0510-12 doi: 10.1039/C9NR09713A – ident: key-10.14336/AD.2021.0510-2 doi: 10.1002/cne.901850307 – ident: key-10.14336/AD.2021.0510-66 doi: 10.1166/jnn.2009.GR09 – ident: key-10.14336/AD.2021.0510-44 doi: 10.1586/14737175.2015.1028369 – ident: key-10.14336/AD.2021.0510-3 doi: 10.1016/j.jconrel.2015.02.027 – ident: key-10.14336/AD.2021.0510-10 doi: 10.1021/acsami.8b08230 – ident: key-10.14336/AD.2021.0510-38 doi: 10.1002/ana.25604 – ident: key-10.14336/AD.2021.0510-73 doi: 10.1016/j.jconrel.2014.07.051 – ident: key-10.14336/AD.2021.0510-31 doi: 10.1016/j.jphys.2019.08.005 – ident: key-10.14336/AD.2021.0510-36 doi: 10.3171/2017.11.FOCUS17627 – ident: key-10.14336/AD.2021.0510-71 doi: 10.1517/17425247.2014.897693 – ident: key-10.14336/AD.2021.0510-40 doi: 10.1038/s41467-018-04529-6 – ident: key-10.14336/AD.2021.0510-69 doi: 10.1016/j.neurobiolaging.2018.06.004 – ident: key-10.14336/AD.2021.0510-63 doi: 10.1016/j.brs.2011.03.007 – ident: key-10.14336/AD.2021.0510-33 doi: 10.1038/s41598-019-45577-2 – ident: key-10.14336/AD.2021.0510-54 doi: 10.1074/jbc.M110.147801 – ident: key-10.14336/AD.2021.0510-64 doi: 10.1016/j.brs.2019.07.024 – ident: key-10.14336/AD.2021.0510-67 doi: 10.1016/j.neuron.2014.12.032 – ident: key-10.14336/AD.2021.0510-11 doi: 10.7150/thno.36718 – ident: key-10.14336/AD.2021.0510-42 doi: 10.1016/j.ultrasmedbio.2004.04.010 – ident: key-10.14336/AD.2021.0510-21 doi: 10.1186/s13195-019-0569-x – ident: key-10.14336/AD.2021.0510-53 doi: 10.1007/978-3-642-45106-5_5 – ident: key-10.14336/AD.2021.0510-14 doi: 10.1073/pnas.1908658117 – ident: key-10.14336/AD.2021.0510-62 doi: 10.1159/000490349 – ident: key-10.14336/AD.2021.0510-51 doi: 10.3389/fnmol.2014.00046 – ident: key-10.14336/AD.2021.0510-1 doi: 10.1002/alz.12068 – ident: key-10.14336/AD.2021.0510-74 doi: 10.1016/j.ultrasmedbio.2007.12.015 – ident: key-10.14336/AD.2021.0510-7 doi: 10.1093/brain/awx052 – ident: key-10.14336/AD.2021.0510-20 doi: 10.7150/thno.34388 – ident: key-10.14336/AD.2021.0510-32 doi: 10.1371/journal.pone.0002175 – ident: key-10.14336/AD.2021.0510-65 doi: 10.1084/jem.20171406 – ident: key-10.14336/AD.2021.0510-27 doi: 10.1016/j.trci.2019.06.007 – ident: key-10.14336/AD.2021.0510-52 doi: 10.1093/brain/awy132 – ident: key-10.14336/AD.2021.0510-24 doi: 10.2991/mseee-17.2017.36 – ident: key-10.14336/AD.2021.0510-23 doi: 10.1038/srep09671 – ident: key-10.14336/AD.2021.0510-22 doi: 10.1038/s41598-020-73151-8 – ident: key-10.14336/AD.2021.0510-9 doi: 10.1038/s41598-018-31071-8 – ident: key-10.14336/AD.2021.0510-4 doi: 10.1016/j.addr.2011.11.010 – ident: key-10.14336/AD.2021.0510-5 doi: 10.1371/journal.pone.0010549 – ident: key-10.14336/AD.2021.0510-19 doi: 10.7150/thno.28717 – ident: key-10.14336/AD.2021.0510-26 doi: 10.1016/j.brs.2020.03.016 – ident: key-10.14336/AD.2021.0510-35 doi: 10.1016/j.neuropharm.2016.02.014 – ident: key-10.14336/AD.2021.0510-55 doi: 10.1126/science.7046051 – ident: key-10.14336/AD.2021.0510-50 doi: 10.1016/j.jconrel.2010.10.038 – ident: key-10.14336/AD.2021.0510-28 doi: 10.1002/advs.201902583 – ident: key-10.14336/AD.2021.0510-41 doi: 10.1073/pnas.2002571117 – ident: key-10.14336/AD.2021.0510-15 doi: 10.1016/j.expneurol.2013.05.008 – ident: key-10.14336/AD.2021.0510-47 doi: 10.1038/jcbfm.2014.71 – ident: key-10.14336/AD.2021.0510-76 doi: 10.3389/fnins.2019.01350
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Snippet	Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound... Alzheimer’s disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound...
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StartPage	1977
SubjectTerms	Alzheimer's disease Care and treatment Diagnosis Diagnosis, Ultrasonic Review
Title	The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies
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