The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies

Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in...

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Bibliographic Details
Published in:Aging and disease Vol. 12; no. 8; pp. 1977 - 2002
Main Authors: Liu, Xiaodan, Naomi, S. Sta Maria, Sharon, Wu Lin, Russell, E. Jacobs
Format: Journal Article
Language:English
Published: United States JKL International 01.12.2021
JKL International LLC
Subjects:
Alzheimer's disease
Care and treatment
Diagnosis
Diagnosis, Ultrasonic
Review
United States
systematic review
Focused ultrasound (FUS)
Alzheimer’s disease (AD)
ISSN:2152-5250, 2152-5250
Online Access:Get full text
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Summary:Alzheimer's disease (AD) affects the basic ability to function and has imposed an immense burden on the community and health care system. Focused ultrasound (FUS) has recently been proposed as a novel noninvasive therapeutic approach for AD. However, systematic reviews on the FUS application in AD treatment have not been forthcoming. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria to summarize the techniques associated with safety and efficacy, as well as possible underlying mechanisms of FUS effects on AD in animal and human studies. Animal studies demonstrated FUS with microbubbles (FUS-MB) induced blood-brain-barrier (BBB) opening that could facilitate various therapeutic agents entering the brain. Repeated FUS-MB and FUS stimulation can relieve AD pathology and improve cognitive and memory function. Human studies showed repeated FUS-MB are well tolerated with few adverse events and FUS stimulation could enhance local perfusion and neural function, which correlated with cognitive improvement. We conclude that FUS is a feasible and safe therapeutic and drug delivery strategy for AD. However, FUS treatment on humans is still in the early stages and requires further optimization and standardization.
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ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2021.0510