Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

In HIV-1, the ability to mount antibody responses to conserved, neutralizing epitopes is critical for protection. Here we have studied the light chain usage of human and rhesus macaque antibodies targeted to a dominant region of the HIV-1 envelope second variable (V2) region involving lysine (K) 169...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 41; H. 6; S. 909
Hauptverfasser:	Wiehe, Kevin, Easterhoff, David, Luo, Kan, Nicely, Nathan I, Bradley, Todd, Jaeger, Frederick H, Dennison, S Moses, Zhang, Ruijun, Lloyd, Krissey E, Stolarchuk, Christina, Parks, Robert, Sutherland, Laura L, Scearce, Richard M, Morris, Lynn, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Sinangil, Faruk, Phogat, Sanjay, Michael, Nelson L, Kim, Jerome H, Kelsoe, Garnett, Montefiori, David C, Tomaras, Georgia D, Bonsignori, Mattia, Santra, Sampa, Kepler, Thomas B, Alam, S Munir, Moody, M Anthony, Liao, Hua-Xin, Haynes, Barton F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.12.2014
Schlagworte:	AIDS Vaccines Amino Acid Sequence Animals Antibodies, Viral - metabolism Antibody Affinity - genetics B-Lymphocytes - immunology Cells, Cultured Clinical Trials as Topic Conserved Sequence - genetics Epitope Mapping Epitopes, B-Lymphocyte - genetics Epitopes, B-Lymphocyte - immunology Epitopes, B-Lymphocyte - metabolism HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HIV Infections - immunology HIV Infections - prevention & control HIV-1 - immunology Humans Immunoglobulin Light Chains - metabolism Macaca mulatta Molecular Sequence Data Mutation - genetics Phylogeny Protein Binding - genetics Protein Engineering
ISSN:	1097-4180, 1097-4180
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