Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression

•Effects of chronic unpredictable prenatal stress were tested in adult offspring.•Prenatal stress impaired spatial memory in adult male and female offspring.•Prenatally stressed females had less H3 acetylation and higher DNMT1 levels.•Prenatally stressed females had higher plasma corticosterone leve...

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Bibliographic Details
Published in:	Behavioural brain research Vol. 281; pp. 1 - 8
Main Authors:	Benoit, Jamie D., Rakic, Pasko, Frick, Karyn M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.03.2015
Subjects:	Acetylation Animals Chronic unpredictable stress Corticosterone - blood DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA methyltransferase Epigenesis, Genetic Female Gene Expression Heterochromatin - metabolism Hippocampus - metabolism Histone acetylation Histones - genetics Male Maze Learning Memory Disorders Mice Mice, Inbred C57BL Morris water maze Mouse Pregnancy Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - psychology Risk Factors Sex differences Sex Factors Spatial Memory Stress, Psychological - blood Stress, Psychological - complications Stress, Psychological - genetics Stress, Psychological - psychology Chronic unpredictable stress Sex differences DNA methyltransferase Histone acetylation Morris water maze Mouse
ISSN:	0166-4328, 1872-7549, 1872-7549
Online Access:	Get full text
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