Simplicity is the Ultimate Sophistication—Crosstalk of Post-translational Modifications on the RNA Polymerase II

[Display omitted] •The largest subunit of RNA Pol II is heavily post-translational modified during transcription.•These modifications now can be accurately mapped by mass spectrometry.•The crosstalk among residue modifications results in differentiated transcriptional outcomes.•The Pol II modificati...

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Bibliographic Details
Published in:	Journal of molecular biology Vol. 433; no. 14; p. 166912
Main Authors:	Venkat Ramani, Mukesh Kumar, Yang, Wanjie, Irani, Seema, Zhang, Yan
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 09.07.2021
Subjects:	chromatin Chromatin - genetics Chromatin - metabolism crosstalk DNA-directed RNA polymerase Gene Expression Regulation histone Histone Code histones Humans landscapes molecular biology Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein Processing, Post-Translational RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - metabolism RNA Processing, Post-Transcriptional transcription transcription initiation Transcription, Genetic histone transcription crosstalk phosphorylation RNA polymerase II
ISSN:	0022-2836, 1089-8638, 1089-8638
Online Access:	Get full text
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