ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics

ERBB receptors were linked to human cancer pathogenesis approximately three decades ago. Biomedical investigators have since developed substantial understanding of the biology underlying the dependence of cancers on aberrant ERBB receptor signaling. An array of cancer-associated genetic alterations...

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Veröffentlicht in:	Cancer cell Jg. 25; H. 3; S. 282
Hauptverfasser:	Arteaga, Carlos L, Engelman, Jeffrey A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.03.2014
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - therapeutic use Drug Resistance, Neoplasm - genetics ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Humans Mice Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Receptor, ErbB-4 Signal Transduction
ISSN:	1878-3686, 1878-3686
Online-Zugang:	Weitere Angaben
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