Two individuals with potential monkeypox virus reinfection

Over 80 000 mpox (formerly known as monkeypox) cases have been confirmed worldwide and recovered individuals are considered protected against reinfection.1–3 However, an individual with apparent reinfection has been recently reported.4 In this Comment we describe two individuals with potential monke...

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Published in:The Lancet infectious diseases Vol. 23; no. 5; pp. 522 - 524
Main Authors: Raccagni, Angelo Roberto, Canetti, Diana, Mileto, Davide, Tamburini, Andrea Marco, Candela, Caterina, Albarello, Luca, Bracchitta, Fiorenza, Mancon, Alessandro, Micheli, Valeria, Gismondo, Maria Rita, Castagna, Antonella, Nozza, Silvia
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 01.05.2023
Elsevier Limited
Subjects:
Chlamydia
Comment
Educational materials
HIV
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Monkeypox virus - genetics
Mpox
Mpox (monkeypox) - epidemiology
Proctitis
Rectum
Reinfection
Severe acute respiratory syndrome coronavirus 2
Viruses
Spain
ISSN:1473-3099, 1474-4457, 1474-4457
Online Access:Get full text
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Summary:Over 80 000 mpox (formerly known as monkeypox) cases have been confirmed worldwide and recovered individuals are considered protected against reinfection.1–3 However, an individual with apparent reinfection has been recently reported.4 In this Comment we describe two individuals with potential monkeypox virus reinfection at San Raffaele Hospital, Milan, Italy (figure; see appendix for details on testing and results). Monkeypox virus PCR was positive for lesion, rectal, and oropharyngeal swabs with cycle threshold values ranging between 18 and 32, with concurrent chlamydia proctitis. Anoscopy revealed mucosal congestion with erosions and ulcerations, and a rectal swab was positive for both monkeypox virus with a cycle threshold value of 37, and for chlamydia.
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ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(23)00185-8