Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans

Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic adverse events associated with NFT exposure, there is still limited understanding of the interplay between NFT exposure, its disposition, and the...

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Veröffentlicht in:	Pharmaceutics Jg. 15; H. 9; S. 2199
Hauptverfasser:	Sharma, Raju Prasad, Burgers, Elsje J., Beltman, Joost B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Basel MDPI AG 25.08.2023 MDPI
Schlagworte:	Antibiotics Drug dosages drug-induced liver injury Health aspects Liver Medical research Medicine, Experimental Nitrofurantoin Normal distribution Pharmacokinetics Physiological aspects physiologically based pharmacokinetic model Physiology Plasma Rabbits renal insufficiency Simulation methods Urinary tract diseases Urinary tract infections Urine Urogenital system Timor-Leste
ISSN:	1999-4923, 1999-4923
Online-Zugang:	Volltext
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