Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification

Premature infants with bronchopulmonary dysplasia (BPD) have impaired alveolar gas exchange due to alveolar simplification and dysmorphic pulmonary vasculature. Advances in clinical care have improved survival for infants with BPD, but the overall incidence of BPD remains unchanged because we lack s...

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Bibliographic Details
Published in:	eLife Vol. 13
Main Authors:	Khan, Imran S, Molina, Christopher, Ren, Xin, Auyeung, Vincent C, Cohen, Max, Tsukui, Tatsuya, Atakilit, Amha, Sheppard, Dean
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 11.12.2024 eLife Sciences Publications, Ltd eLife Sciences Publications Ltd
Subjects:	Analysis Animals Animals, Newborn bronchopulmonary dysplasia Bronchopulmonary Dysplasia - metabolism Bronchopulmonary Dysplasia - pathology Cell Proliferation Developmental Biology Disease Models, Animal Dysplasia Female Gene expression Humans hyperoxia Hyperoxia - metabolism Infants (Premature) lung development Mice Mice, Inbred C57BL myofibroblast Myofibroblasts - metabolism Myofibroblasts - pathology Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology RNA sequencing Signal Transduction Transforming Growth Factor beta - metabolism Transforming growth factors Canada California United States Massachusetts mouse hyperoxia bronchopulmonary dysplasia myofibroblast developmental biology lung development
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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