Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer

Background: Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) provides selective uptake and conversion of ALA into protoporphyrin IX (PpIX) in actinic keratosis and squamous cell carcinoma, yet large response variations in effect are common between individuals. The aim of this study was to...

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Bibliographic Details
Published in:	British journal of cancer Vol. 115; no. 7; pp. 805 - 813
Main Authors:	de Souza, Ana Luiza Ribeiro, Marra, Kayla, Gunn, Jason, Samkoe, Kimberley S, Kanick, Stephen Chad, Davis, Scott C, Chapman, M Shane, Maytin, Edward V, Hasan, Tayyaba, Pogue, Brian W
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.09.2016 Nature Publishing Group
Subjects:	631/154/436 692/699/67/1059 692/699/67/1813 Acids Aminolevulinic Acid - therapeutic use Animals Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cell Line, Tumor Deferoxamine - pharmacology Deferoxamine - therapeutic use Dose Fractionation Dose-Response Relationship, Radiation Drug Resistance Epidemiology FDA approval Female Fractionation Heme - biosynthesis Humans Lasers, Semiconductor Light Lighting - instrumentation Lighting - methods Medical research Mice Mice, Nude Molecular Medicine Oncology Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacokinetics Photosensitizing Agents - therapeutic use Protoporphyrins - pharmacokinetics Protoporphyrins - therapeutic use Random Allocation Siderophores - pharmacology Siderophores - therapeutic use Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - pathology Translational Therapeutics Tumor Burden Xenograft Model Antitumor Assays Brazil United States > US aminolevulinic acid fractionation dose protoporphyrin IX photodynamic iron chelator
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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