Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19

[...]we propose that measurement of ACE2 level may help identify individuals at risk of severe infection where targeted shielding can be used and could provide a novel therapeutic target. The resultant increased sACE2 may act as a “dummy” receptor, binding the S protein on circulating virus. [...]hi...

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Vydáno v:The American journal of cardiology Ročník 130; s. 161 - 162
Hlavní autoři: Gue, Ying Xuan, Kanji, Rahim, Markides, Vias, Gorog, Diana Adrienne
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.09.2020
Elsevier Limited
Témata:
ACE2
Angiotensin
Angiotensin-Converting Enzyme 2
Betacoronavirus
Binding
Coronavirus Infections - physiopathology
Coronaviruses
COVID-19
Enzymes
Gene Expression Regulation
Humans
Hypertension
Infections
Kidney diseases
Metabolic syndrome
Pandemics
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - genetics
Pneumonia, Viral - physiopathology
Proteins
Receptors
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Shielding
Viral diseases
Viruses
ISSN:0002-9149, 1879-1913, 1879-1913
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Shrnutí:[...]we propose that measurement of ACE2 level may help identify individuals at risk of severe infection where targeted shielding can be used and could provide a novel therapeutic target. The resultant increased sACE2 may act as a “dummy” receptor, binding the S protein on circulating virus. [...]higher numbers of ACE2 receptors expressed before first binding event may lead to higher sACE2 level and reduced circulating SARS-CoV-2 with “active” S protein sites, reduced numbers of affected host cells, and less systemic impact. [...]conditions that upregulate ACE2 may confer protection, whereas reduced ACE2 expression may result in more severe disease.
Bibliografie:ObjectType-Article-1
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ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2020.06.002