Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Neurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research identified three neuroprotective drugs acting on different axonal pathobiologies. We aimed to test the efficacy of these drugs in...

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Bibliographic Details
Published in:	Lancet neurology Vol. 19; no. 3; pp. 214 - 225
Main Authors:	Chataway, Jeremy, De Angelis, Floriana, Connick, Peter, Parker, Richard A, Plantone, Domenico, Doshi, Anisha, John, Nevin, Stutters, Jonathan, MacManus, David, Prados Carrasco, Ferran, Barkhof, Frederik, Ourselin, Sebastien, Braisher, Marie, Ross, Moira, Cranswick, Gina, Pavitt, Sue H, Giovannoni, Gavin, Gandini Wheeler-Kingshott, Claudia Angela, Hawkins, Clive, Sharrack, Basil, Bastow, Roger, Weir, Christopher J, Stallard, Nigel, Chandran, Siddharthan, Gandini Wheeler-Kingshott, Claudia A.M., Williams, Thomas, Beyene, Tiggy, Bassan, Vanessa, Zapata, Alvin, Lyle, Dawn, Cameron, James, Mollison, Daisy, Colville, Shuna, Dhillon, Baljean, Weir, Christopher J., Parker, Richard A., Gnanapavan, Sharmilee, Nicholas, Richard, Rashid, Waqar, Aram, Julia, Ford, Helen, Overell, James, Young, Carolyn, Arndt, Heinke, Duddy, Martin, Guadagno, Joe, Evangelou, Nikolaos, Craner, Matthew, Palace, Jacqueline, Hobart, Jeremy, Paling, David, Kalra, Seema, McLean, Brendan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.03.2020 Elsevier Limited Lancet Pub. Group
Subjects:	Administration, Oral Adult Amiloride Amiloride - therapeutic use Atrophy Axon guidance Brain Clinical trials Coronary artery Coronary artery disease Dementia Disease Progression Double-Blind Method Double-blind studies Drugs Encephalomyelitis Female Fluoxetine Fluoxetine - therapeutic use Heart diseases Humans Huntingtons disease Lung cancer Magnetic Resonance Imaging Male Metabolism Metastases Middle Aged Motor neurone disease Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis, Chronic Progressive - drug therapy Nervous system Neurodegeneration Neuroprotection Neuroprotective Agents - therapeutic use Parkinson's disease Patients Riluzole - therapeutic use Subject heading schemes Systematic review Thrombosis Treatment Outcome United Kingdom > UK
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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