Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells

T helper subsets, Th1 and Th2, which are associated with different types of immune reactions, are distinguished by their cytokines' profiles and expression of different chemokine receptors, that may differentially influence their migratory capacity. The present study examined the expression of...

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Vydáno v:Journal of neuroimmunology Ročník 163; číslo 1; s. 157 - 164
Hlavní autoři: Abraham, Michal, Shapiro, Sarah, Karni, Arnon, Weiner, Howard L., Miller, Ariel
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.06.2005
Témata:
Adult
Animals
Cell Movement - immunology
Cells, Cultured
Chemokines
Clone Cells
Gelatinases
Gene Expression Regulation, Enzymologic - immunology
Humans
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 2 - secretion
Matrix Metalloproteinase 9 - biosynthesis
Matrix Metalloproteinase 9 - secretion
Mice
Mice, Inbred AKR
Mice, Transgenic
Middle Aged
MMPs
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - enzymology
Multiple Sclerosis, Relapsing-Remitting - immunology
Multiple Sclerosis, Relapsing-Remitting - pathology
Th1 and Th2 cells
Th1 Cells - cytology
Th1 Cells - enzymology
Th1 Cells - secretion
Th2 Cells - cytology
Th2 Cells - enzymology
Th2 Cells - secretion
Multiple sclerosis
Th1 and Th2 cells
Gelatinases
Chemokines
MMPs
ISSN:0165-5728, 1872-8421
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Shrnutí:T helper subsets, Th1 and Th2, which are associated with different types of immune reactions, are distinguished by their cytokines' profiles and expression of different chemokine receptors, that may differentially influence their migratory capacity. The present study examined the expression of matrix metalloproteinases, (MMP)-2 and MMP-9, by the two CD4 + Th cell subsets and the role of these proteases in their migration. We observed that migration of CD4 + T cells is dependent on the gelatinases, and that the migratory capacity of Th1 is higher than Th2 cells. In addition, Th1 in comparison to Th2 cells, from both human (healthy subjects and multiple sclerosis (MS) patients) as well as from murine origin, secrete higher levels of MMP-2 and MMP-9. These novel findings contribute to the understanding of the physiological Th1 and Th2 immune responses as well as the enhanced Th1 reactivity in immune-mediated diseases, such as MS, in which enhanced levels of MMP-2 and MMP-9 are associated with disease processes.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.02.001