The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still f...

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Veröffentlicht in:	Antioxidants & redox signaling Jg. 26; H. 10; S. 501
Hauptverfasser:	Gerber, Philipp A, Rutter, Guy A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2017
Schlagworte:	Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Diabetes Mellitus - etiology Diabetes Mellitus - metabolism Diabetes Mellitus - therapy Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - therapy Glucose - metabolism Humans Hypoxia - metabolism Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Islets of Langerhans - metabolism Islets of Langerhans Transplantation Lipid Metabolism Mitochondria - metabolism Oxidative Stress Reactive Oxygen Species - metabolism Zinc - metabolism beta cell hypoxia insulin secretion diabetes zinc
ISSN:	1557-7716, 1557-7716
Online-Zugang:	Weitere Angaben
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