New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage

Vascular leak is a key driver of organ injury in diseases, and strategies that reduce enhanced permeability and vascular inflammation are promising therapeutic targets. Activation of the angiopoietin-1 (ANG1)-Tie2 tyrosine kinase signaling pathway is an important regulator of vascular quiescence. He...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 118; no. 1; pp. 423 - 432
Main Authors:	Liu, Pan, Ryczko, Michael, Xie, Xinfang, Baardsnes, Jason, Lord‐Dufour, Simon, Duroche, Yves, Hicks, Emily Anne, Taiyab, Aftab, Sheardown, Heather, Quaggin, Susan E, Jin, Jing
Format:	Journal Article
Language:	English
Published:	United States Wiley 01.01.2021 Wiley Subscription Services, Inc
Subjects:	angiopoetin 1 Angiopoietin Angiopoietin-1 - biosynthesis Angiopoietin-1 - genetics Angiopoietin-1 - pharmacology angiopoietin‐Tie2 pathway Animals chimeric protein Complement C4b-Binding Protein - biosynthesis Complement C4b-Binding Protein - genetics Complement C4b-Binding Protein - pharmacology Complement component C4 Extracellular matrix Female Fusion protein Growth factors HEK293 Cells Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Injection Injury prevention Intravenous administration Kinases Leakage Lipopolysaccharides Mice Mice, Inbred BALB C Oligomerization Permeability Phosphorylation Protein Domains Protein-tyrosine kinase Proteins Rabbits Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Respiratory distress syndrome Respiratory Distress Syndrome - drug therapy Respiratory Distress Syndrome - metabolism Respiratory Distress Syndrome - pathology Sepsis Sepsis - drug therapy Sepsis - metabolism Sepsis - pathology Signal transduction Stability Tyrosine Vascular Diseases - drug therapy Vascular Diseases - metabolism Vascular Diseases - pathology Vascular endothelial growth factor vascular perme vascular permeability angiopoetin 1 vascular permeability angiopoietin-Tie2 pathway chimeric protein
ISSN:	1097-0290, 0006-3592, 1097-0290
Online Access:	Get full text
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