A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairoviridae ) exhibits extensive genomic sequence divers...

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Bibliographic Details
Published in:	eLife Vol. 9
Main Authors:	Hua, Brian L, Scholte, Florine EM, Ohlendorf, Valerie, Kopp, Anne, Marklewitz, Marco, Drosten, Christian, Nichol, Stuart T, Spiropoulou, Christina, Junglen, Sandra, Bergeron, Éric
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 21.10.2020 eLife Sciences Publications, Ltd eLife Sciences Publications Ltd
Subjects:	Amino Acid Substitution - genetics Amino acids Animals Arachnid Vectors - virology Cells (Biology) congo hemorrhagic fever virus Disease transmission Epidemics Europe Genetic aspects Genetic research Genetic Variation - genetics Genome, Viral - genetics Genomes Genomics Health aspects Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity Hemorrhagic Fever, Crimean - virology Hemorrhagic fevers Humans Infection Medical research membrane fusion Microbiology and Infectious Disease nairoviridae phylogenetic Phylogeny Tick-borne diseases tick-borne virus Ticks - virology virus pathogenesis Europe nairoviridae tick-borne virus phylogenetic infectious disease microbiology virus pathogenesis congo hemorrhagic fever virus virus membrane fusion
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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