hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer

MicroRNA (miRNA) expression alterations have been described in cancer. Many cancers are characterized by areas of hypoxia, enhanced hypoxia-inducible factor (HIF) levels, and increased expression of hypoxically regulated genes, all of which correlate with patient outcome. We examined hypoxia-induced...

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Veröffentlicht in:	Clinical cancer research Jg. 14; H. 5; S. 1340
Hauptverfasser:	Camps, Carme, Buffa, Francesca M, Colella, Stefano, Moore, John, Sotiriou, Christos, Sheldon, Helen, Harris, Adrian L, Gleadle, Jonathan M, Ragoussis, Jiannis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2008
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - genetics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics MicroRNAs - physiology Middle Aged Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - pharmacology Transfection Tumor Cells, Cultured Von Hippel-Lindau Tumor Suppressor Protein - genetics
ISSN:	1078-0432
Online-Zugang:	Weitere Angaben
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