Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 344; číslo 6182; s. 380
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 25.04.2014
Témata:
Animals
Blood
Feeding Behavior
Female
Genes, Insect
Genome, Insect
Insect Proteins - genetics
Insect Proteins - physiology
Insect Vectors - genetics
Insect Vectors - microbiology
Insect Vectors - parasitology
Insect Vectors - physiology
Microbiota
Molecular Sequence Annotation
Molecular Sequence Data
Reproduction - genetics
Salivary Glands - parasitology
Salivary Glands - physiology
Sensation - genetics
Sequence Analysis, DNA
Symbiosis
Trypanosoma - physiology
Trypanosomiasis, African - transmission
Tsetse Flies - genetics
Tsetse Flies - microbiology
Tsetse Flies - parasitology
Tsetse Flies - physiology
Wolbachia - genetics
Wolbachia - physiology
ISSN:1095-9203, 1095-9203
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Shrnutí:Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.1249656