Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 344; no. 6182; p. 380 |
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| Format: | Journal Article |
| Language: | English |
| Published: |
United States
25.04.2014
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| Subjects: | |
| ISSN: | 1095-9203, 1095-9203 |
| Online Access: | Get more information |
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| Abstract | Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. |
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| AbstractList | Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24763584$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Contributor | Wilson, Richard K Swain, Martin T Schoofs, Liliane Sanders, Mandy J Ooi, Cher-Pheng Hattori, Masahira Ravel, Sophie Zhang, Qirui Winzerling, Joy J Warren, Wesley Koekemoer, Jacobus J O Berriman, Matthew Attardo, Geoffrey M Baumann, Aaron A Obiero, George F O Falchetto, Marco Field, Linda M Toyoda, Atsushi Cotton, James A Lawson, Daniel Caers, Jelle Geiser, L Touré, Yeya Hughes, Daniel S T Meuti, Megan E Mireji, Paul O Lehane, Michael J Marco, Heather G Scolari, Francesca Aksoy, Serap Suzuki, Yutaka Price, David P Michalkova, Veronika Inoue, Noboru Larkin, Denis M Darby, Alistair C Hide, Winston Taylor, Todd D Ribeiro, José M C Srivastava, Tulika P Hertz-Fowler, Christiane Kibet, Caleb K Megy, Karyn Haines, Lee R Christoffels, Alan Sim, Cheolho Denlinger, David L Jonas, Mario Nyanjom, Steven R G Dashti, Zahra Jalali Sefid Telleria, Erich L Marucha, Kevin K Sharma, Vineet Bourtzis, Kostas Hu, Wanqi Macharia, Rosaline W Riehle, Michael A Peyton, Justin T Zhou, Jing-Jiang Gomulski, Ludvik M Fu, Shuhua Van Den Abbeele, Jan Benoit, Joshua B Rose, Clair P |
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| PublicationYear | 2014 |
| References | 24763563 - Science. 2014 Apr 25;344(6182):349-50. doi: 10.1126/science.344.6182.349. |
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| Snippet | Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and... |
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| StartPage | 380 |
| SubjectTerms | Animals Blood Feeding Behavior Female Genes, Insect Genome, Insect Insect Proteins - genetics Insect Proteins - physiology Insect Vectors - genetics Insect Vectors - microbiology Insect Vectors - parasitology Insect Vectors - physiology Microbiota Molecular Sequence Annotation Molecular Sequence Data Reproduction - genetics Salivary Glands - parasitology Salivary Glands - physiology Sensation - genetics Sequence Analysis, DNA Symbiosis Trypanosoma - physiology Trypanosomiasis, African - transmission Tsetse Flies - genetics Tsetse Flies - microbiology Tsetse Flies - parasitology Tsetse Flies - physiology Wolbachia - genetics Wolbachia - physiology |
| Title | Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24763584 https://www.proquest.com/docview/1519263828 |
| Volume | 344 |
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