Emerging Role of cAMP/AMPK Signaling

The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochond...

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Vydáno v:Cells (Basel, Switzerland) Ročník 11; číslo 2; s. 308
Hlavní autoři: Aslam, Muhammad, Ladilov, Yury
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 17.01.2022
MDPI
Témata:
Adenosine
Adenylate cyclase
adenylyl cyclase
Aging
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
Autophagy
Binding sites
cAMP
Cyclic AMP
Cyclic AMP - metabolism
Diabetes mellitus
Energy
Energy balance
Enzymes
EPAC
Epinephrine
Glucagon
Glucose metabolism
Homeostasis
Humans
Ischemia
Kinases
Lipid Metabolism
Localization
Mammalian cells
Metabolic disorders
Metabolism
Mitochondria
mitophagy
Models, Biological
Phosphatase
Phosphorylation
Physiology
PKA
Protein Biosynthesis
Protein kinase
Proteins
Regulation
Review
Sensors
Signal Transduction
mitophagy
autophagy
PKA
adenylyl cyclase
AMPK
cAMP
EPAC
ISSN:2073-4409, 2073-4409
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Abstract The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochondrial biogenesis, autophagy, and glucose and lipid metabolism. Thus, understanding the pathways regulating AMPK activity is crucial for developing strategies to treat metabolic disorders. Mounting evidence suggests the presence of a link between cyclic AMP (cAMP) and AMPK signaling. cAMP signaling is known to be activated in circumstances of physiological and metabolic stress due to the release of stress hormones, such as adrenaline and glucagon, which is followed by activation of membrane-bound adenylyl cyclase and elevation of cellular cAMP. Because the majority of physiological stresses are associated with elevated energy consumption, it is not surprising that activation of cAMP signaling may promote AMPK activity. Aside from the physiological role of the cAMP/AMPK axis, numerous reports have suggested its role in several pathologies, including inflammation, ischemia, diabetes, obesity, and aging. Furthermore, novel reports have provided more mechanistic insight into the regulation of the cAMP/AMPK axis. In particular, the role of distinct cAMP microdomains generated by soluble adenylyl cyclase in regulating basal and induced AMPK activity has recently been demonstrated. In the present review, we discuss current advances in the understanding of the regulation of the cAMP/AMPK axis and its role in cellular homeostasis and explore some translational aspects.
AbstractList The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochondrial biogenesis, autophagy, and glucose and lipid metabolism. Thus, understanding the pathways regulating AMPK activity is crucial for developing strategies to treat metabolic disorders. Mounting evidence suggests the presence of a link between cyclic AMP (cAMP) and AMPK signaling. cAMP signaling is known to be activated in circumstances of physiological and metabolic stress due to the release of stress hormones, such as adrenaline and glucagon, which is followed by activation of membrane-bound adenylyl cyclase and elevation of cellular cAMP. Because the majority of physiological stresses are associated with elevated energy consumption, it is not surprising that activation of cAMP signaling may promote AMPK activity. Aside from the physiological role of the cAMP/AMPK axis, numerous reports have suggested its role in several pathologies, including inflammation, ischemia, diabetes, obesity, and aging. Furthermore, novel reports have provided more mechanistic insight into the regulation of the cAMP/AMPK axis. In particular, the role of distinct cAMP microdomains generated by soluble adenylyl cyclase in regulating basal and induced AMPK activity has recently been demonstrated. In the present review, we discuss current advances in the understanding of the regulation of the cAMP/AMPK axis and its role in cellular homeostasis and explore some translational aspects.
The 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochondrial biogenesis, autophagy, and glucose and lipid metabolism. Thus, understanding the pathways regulating AMPK activity is crucial for developing strategies to treat metabolic disorders. Mounting evidence suggests the presence of a link between cyclic AMP (cAMP) and AMPK signaling. cAMP signaling is known to be activated in circumstances of physiological and metabolic stress due to the release of stress hormones, such as adrenaline and glucagon, which is followed by activation of membrane-bound adenylyl cyclase and elevation of cellular cAMP. Because the majority of physiological stresses are associated with elevated energy consumption, it is not surprising that activation of cAMP signaling may promote AMPK activity. Aside from the physiological role of the cAMP/AMPK axis, numerous reports have suggested its role in several pathologies, including inflammation, ischemia, diabetes, obesity, and aging. Furthermore, novel reports have provided more mechanistic insight into the regulation of the cAMP/AMPK axis. In particular, the role of distinct cAMP microdomains generated by soluble adenylyl cyclase in regulating basal and induced AMPK activity has recently been demonstrated. In the present review, we discuss current advances in the understanding of the regulation of the cAMP/AMPK axis and its role in cellular homeostasis and explore some translational aspects.The 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochondrial biogenesis, autophagy, and glucose and lipid metabolism. Thus, understanding the pathways regulating AMPK activity is crucial for developing strategies to treat metabolic disorders. Mounting evidence suggests the presence of a link between cyclic AMP (cAMP) and AMPK signaling. cAMP signaling is known to be activated in circumstances of physiological and metabolic stress due to the release of stress hormones, such as adrenaline and glucagon, which is followed by activation of membrane-bound adenylyl cyclase and elevation of cellular cAMP. Because the majority of physiological stresses are associated with elevated energy consumption, it is not surprising that activation of cAMP signaling may promote AMPK activity. Aside from the physiological role of the cAMP/AMPK axis, numerous reports have suggested its role in several pathologies, including inflammation, ischemia, diabetes, obesity, and aging. Furthermore, novel reports have provided more mechanistic insight into the regulation of the cAMP/AMPK axis. In particular, the role of distinct cAMP microdomains generated by soluble adenylyl cyclase in regulating basal and induced AMPK activity has recently been demonstrated. In the present review, we discuss current advances in the understanding of the regulation of the cAMP/AMPK axis and its role in cellular homeostasis and explore some translational aspects.
Author Ladilov, Yury
Aslam, Muhammad
AuthorAffiliation 1 Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany; muhammad.aslam@physiologie.med.uni-giessen.de
4 Heart Center Brandenburg, Department of Cardiovascular Surgery, University Hospital Brandenburg, Medical School Theodor Fontane, Ladeburger Straße 17, 16321 Bernau bei Berlin, Germany
3 DZHK (German Centre for Cardiovascular Research), Partner Site Rhein-Main, 61231 Bad Nauheim, Germany
2 Department of Cardiology, Kerckhoff Clinic GmbH, 61231 Bad Nauheim, Germany
AuthorAffiliation_xml – name: 2 Department of Cardiology, Kerckhoff Clinic GmbH, 61231 Bad Nauheim, Germany
– name: 3 DZHK (German Centre for Cardiovascular Research), Partner Site Rhein-Main, 61231 Bad Nauheim, Germany
– name: 4 Heart Center Brandenburg, Department of Cardiovascular Surgery, University Hospital Brandenburg, Medical School Theodor Fontane, Ladeburger Straße 17, 16321 Bernau bei Berlin, Germany
– name: 1 Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany; muhammad.aslam@physiologie.med.uni-giessen.de
Author_xml – sequence: 1
  givenname: Muhammad
  orcidid: 0000-0002-8529-4217
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  fullname: Aslam, Muhammad
– sequence: 2
  givenname: Yury
  orcidid: 0000-0002-9836-8801
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35053423$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords mitophagy
autophagy
PKA
adenylyl cyclase
AMPK
cAMP
EPAC
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and...
The 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and...
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SubjectTerms Adenosine
Adenylate cyclase
adenylyl cyclase
Aging
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
Autophagy
Binding sites
cAMP
Cyclic AMP
Cyclic AMP - metabolism
Diabetes mellitus
Energy
Energy balance
Enzymes
EPAC
Epinephrine
Glucagon
Glucose metabolism
Homeostasis
Humans
Ischemia
Kinases
Lipid Metabolism
Localization
Mammalian cells
Metabolic disorders
Metabolism
Mitochondria
mitophagy
Models, Biological
Phosphatase
Phosphorylation
Physiology
PKA
Protein Biosynthesis
Protein kinase
Proteins
Regulation
Review
Sensors
Signal Transduction
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Title Emerging Role of cAMP/AMPK Signaling
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