A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery

The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have res...

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Vydané v:Metabolites Ročník 9; číslo 11; s. 258
Hlavní autori: Anand, Uttpal, Jacobo-Herrera, Nadia, Altemimi, Ammar, Lakhssassi, Naoufal
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.11.2019
MDPI
Predmet:
Antibiotics
Antimicrobial agents
Antimicrobial resistance
antimicrobial resistant
Ayurvedic medicine
Bacteria
Bacterial infections
Drug development
Drug resistance
Ethnopharmacology
Functional foods & nutraceuticals
Gram-positive bacteria
Herbal medicine
immune response
infectious disease
Infectious diseases
Medicinal plants
Metabolites
Microorganisms
Multidrug resistance
Natural products
Pharmaceutical industry
Phytochemicals
Plants
Public health
R&D
Research & development
Review
Reviews
Secondary metabolites
Traditional Chinese medicine
India
secondary metabolites
antimicrobial resistant
immune response
infectious disease
antibiotics
ISSN:2218-1989, 2218-1989
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Shrnutí:The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have resulted in the emergence of antimicrobial resistance. This has resulted in an increased interest in medicinal plants since 30–50% of current pharmaceuticals and nutraceuticals are plant-derived. The question we address in this review is whether plants, which produce a rich diversity of secondary metabolites, may provide novel antibiotics to tackle MDR microbes and novel chemosensitizers to reclaim currently used antibiotics that have been rendered ineffective by the MDR microbes. Plants synthesize secondary metabolites and phytochemicals and have great potential to act as therapeutics. The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo9110258