Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

During the SARS epidemic in 2003/2004, a number of deletions were observed in ORF8 of SARS-CoV, and eventually deletion variants became predominant, leading to the hypothesis that ORF8 was an evolutionary hot spot for adaptation of SARS-CoV to humans. However, due to the successful control of the SA...

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Bibliographic Details
Published in:	mBio Vol. 11; no. 4
Main Authors:	Su, Yvonne C. F., Anderson, Danielle E., Young, Barnaby E., Linster, Martin, Zhu, Feng, Jayakumar, Jayanthi, Zhuang, Yan, Kalimuddin, Shirin, Low, Jenny G. H., Tan, Chee Wah, Chia, Wan Ni, Mak, Tze Minn, Octavia, Sophie, Chavatte, Jean-Marc, Lee, Raphael T. C., Pada, Surinder, Tan, Seow Yen, Sun, Louisa, Yan, Gabriel Z., Maurer-Stroh, Sebastian, Mendenhall, Ian H., Leo, Yee-Sin, Lye, David Chien, Wang, Lin-Fa, Smith, Gavin J. D.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 21.07.2020
Subjects:	Antibody response Base Sequence Betacoronavirus - genetics Betacoronavirus - immunology Betacoronavirus - physiology Coronaviruses COVID-19 Disease transmission Ecological and Evolutionary Science Editor's Pick Epidemics Epidemiology Fitness Gene deletion Genome, Viral Genomes Humans Immune response Mutation natural selection Open Reading Frames ORF8 Patients phylogeny Regulatory sequences Respiratory diseases SARS-CoV-2 Sequence Deletion Severe acute respiratory syndrome coronavirus 2 Vaccination vaccines Virus Replication Viruses Zoonoses Bangladesh Singapore Australia China Taiwan Spain COVID-19 ORF8 phylogeny natural selection vaccines
ISSN:	2161-2129, 2150-7511, 2150-7511
Online Access:	Get full text
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