ER stress and unfolded protein response in ocular health and disease

The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reti...

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Veröffentlicht in:The FEBS journal Jg. 286; H. 2; S. 399 - 412
Hauptverfasser: Kroeger, Heike, Chiang, Wei‐Chieh, Felden, Julia, Nguyen, Amanda, Lin, Jonathan H.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Blackwell Publishing Ltd 01.01.2019
Schlagworte:
achromatopsia
Aging
AMD
Animal models
Animals
color
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - pathology
Endoplasmic Reticulum Stress
Environmental changes
ER stress
Eye - metabolism
Eye diseases
Eye Diseases - physiopathology
eyes
glaucoma
Humans
Mutation
neurodegernation
Organic chemistry
Protein folding
Proteins
retinal degeneration
RGC
RPE
Signal Transduction
Stress
Unfolded Protein Response
UPR
VEGF
vision
retinal degeneration
RPE
UPR
VEGF
glaucoma
AMD
ER stress
achromatopsia
neurodegernation
RGC
ISSN:1742-464X, 1742-4658, 1742-4658
Online-Zugang:Volltext
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Zusammenfassung:The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme. The Human eye is a vulnerable organ in the body. Many factors can impact the health of the human eye leading to changes in the quality of our vision. The presence of Endoplasmic reticulum stress and the induction of the Unfolded Protein Response are hallmarks of many retinal diseases; and may be potential mechanisms for therapeutic intervention.
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ISSN:1742-464X
1742-4658
1742-4658
DOI:10.1111/febs.14522