Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease

Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in...

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Published in:Biomedicines Vol. 10; no. 6; p. 1408
Main Authors: Bianchi, Nicoletta, Doneda, Luisa, Elli, Luca, Taccioli, Cristian, Vaira, Valentina, Scricciolo, Alice, Lombardo, Vincenza, Terrazzan, Anna, Colapietro, Patrizia, Terranova, Leonardo, Bergamini, Carlo, Vecchi, Maurizio, Scaramella, Lucia, Nandi, Nicoletta, Roncoroni, Leda
Format: Journal Article
Language:English
Published: Basel MDPI AG 14.06.2022
MDPI
Subjects:
Age
Beta cells
Biomarkers
Celiac disease
Cell signaling
Development and progression
Epigenetics
Genetic aspects
Gluten
gluten-free diet
Health aspects
Identification and classification
Inflammation
Lymphoma
MicroRNA
MicroRNAs
miRNA
Ontology
Patients
Post-transcription
Proteins
refractory celiac disease
Transforming growth factor-b
Wnt protein
Italy
ISSN:2227-9059, 2227-9059
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Abstract Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell–cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.
AbstractList Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell–cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.
Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell-cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell-cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.
Audience Academic
Author Taccioli, Cristian
Bianchi, Nicoletta
Bergamini, Carlo
Doneda, Luisa
Elli, Luca
Scaramella, Lucia
Vecchi, Maurizio
Roncoroni, Leda
Colapietro, Patrizia
Lombardo, Vincenza
Scricciolo, Alice
Vaira, Valentina
Terrazzan, Anna
Nandi, Nicoletta
Terranova, Leonardo
AuthorAffiliation 1 Department of Translational Medicine, University of Ferrara, Street L. Borsari 46, 44121 Ferrara, Italy; nicoletta.bianchi@unife.it (N.B.); anna.terrazzan@unife.it (A.T.)
2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Street Pascal 36, 20133 Milan, Italy; luisa.doneda@unimi.it (L.D.); leda.roncoroni@unimi.it (L.R.)
5 Division of Pathology, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Street F. Sforza 35, 20122 Milan, Italy; valentina.vaira@unimi.it
3 Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy; alice.scricciolo@policlinico.mi.it (A.S.); vincenza.lombardo@policlinico.mi.it (V.L.); maurizio.vecchi@unimi.it (M.V.); lucia.scaramella@policlinico.mi.it (L.S.); nicoletta.nandi@unimi.it (N.N.)
4 Department of Animal Medicine, Production and Health, University of Padova, 35020 Legnaro, Italy; cristian.taccioli@unipd.it
6 Depar
AuthorAffiliation_xml – name: 2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Street Pascal 36, 20133 Milan, Italy; luisa.doneda@unimi.it (L.D.); leda.roncoroni@unimi.it (L.R.)
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– name: 6 Department of Pathophysiology and Transplantation, University of Milan, Street F. Sforza 35, 20122 Milan, Italy; patrizia.colapietro@unimi.it
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crossref_primary_10_1002_jbt_70361
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Snippet Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications,...
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SubjectTerms Age
Beta cells
Biomarkers
Celiac disease
Cell signaling
Development and progression
Epigenetics
Genetic aspects
Gluten
gluten-free diet
Health aspects
Identification and classification
Inflammation
Lymphoma
MicroRNA
MicroRNAs
miRNA
Ontology
Patients
Post-transcription
Proteins
refractory celiac disease
Transforming growth factor-b
Wnt protein
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Title Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease
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