Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease

Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in...

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Vydáno v:Biomedicines Ročník 10; číslo 6; s. 1408
Hlavní autoři: Bianchi, Nicoletta, Doneda, Luisa, Elli, Luca, Taccioli, Cristian, Vaira, Valentina, Scricciolo, Alice, Lombardo, Vincenza, Terrazzan, Anna, Colapietro, Patrizia, Terranova, Leonardo, Bergamini, Carlo, Vecchi, Maurizio, Scaramella, Lucia, Nandi, Nicoletta, Roncoroni, Leda
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 14.06.2022
MDPI
Témata:
Age
Beta cells
Biomarkers
Celiac disease
Cell signaling
Development and progression
Epigenetics
Genetic aspects
Gluten
gluten-free diet
Health aspects
Identification and classification
Inflammation
Lymphoma
MicroRNA
MicroRNAs
miRNA
Ontology
Patients
Post-transcription
Proteins
refractory celiac disease
Transforming growth factor-b
Wnt protein
Italy
ISSN:2227-9059, 2227-9059
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Shrnutí:Despite following a gluten-free diet, which is currently the only effective therapy for celiac disease, about 5% of patients can develop serious complications, which in the case of refractory type 2 could evolve towards intestinal lymphoma. In this study, we have identified a set of 15 microRNAs in serum discriminating between the two types of refractory disease. Upregulated miR-770-5p, miR-181b-2-3p, miR-1193, and miR-1226-3p could be useful for the better stratification of patients and the monitoring of disease development, while miR-490-3p was found to be dysregulated in patients with refractory type 1. Finally, by using bioinformatic tools applied to the analysis of the targets of dysregulated microRNAs, we have completed a more precise assessment of their functions. These mainly include the pathway of response to Transforming Growth Factor β cell–cell signaling by Wnt; epigenetic regulation, especially novel networks associated with transcriptional and post-transcriptional alterations; and the well-known inflammatory profiles.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10061408