Fetal sex and the circulating renin–angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension

There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine whether at 15 weeks’ gestation plasma levels of Ang II and Ang-(1–7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted...

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Vydáno v:	Journal of human hypertension Ročník 28; číslo 2; s. 133 - 139
Hlavní autoři:	Sykes, S D, Pringle, K G, Zhou, A, Dekker, G A, Roberts, C T, Lumbers, E R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.02.2014 Nature Publishing Group
Témata:	631/443/494 631/443/592 692/699/75/243/793 Adult Angiotensin Angiotensin I - blood Angiotensin II Angiotensin II - blood Biomarkers - blood Blood Pressure Body mass index Case-Control Studies Development and progression Epidemiology Female Fetuses Gestation Gestational Age Health Administration Humans Hypertension Hypertension in pregnancy Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - etiology Hypertension, Pregnancy-Induced - physiopathology Male Medicine Medicine & Public Health original-article Peptide Fragments - blood Peptidyl-Dipeptidase A - blood Plasma levels Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - etiology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Public Health Renin Renin - blood Renin-Angiotensin System Risk Assessment Risk Factors Sex Sex Determination Analysis Sex Factors Ultrasonography, Doppler Ultrasonography, Prenatal Young Adult gestational hypertension prorenin preeclampsia angiotensin II angiotensin-(1–7) angiotensin-converting enzyme
ISSN:	0950-9240, 1476-5527, 1476-5527
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Shrnutí:	There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine whether at 15 weeks’ gestation plasma levels of Ang II and Ang-(1–7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH ( n =50) or PreE ( n =50) were compared with body mass index-matched controls ( n =100). Women who subsequently developed PreE or GH had increased Ang-(1–7) levels at 15 weeks’ gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks’ gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks’ gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1–7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0950-9240 1476-5527 1476-5527
DOI:	10.1038/jhh.2013.51