Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort
Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role...
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| Veröffentlicht in: | Diabetologia Jg. 65; H. 8; S. 1328 - 1338 |
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Berlin/Heidelberg
Springer Science and Business Media LLC
01.08.2022
Springer Berlin Heidelberg Springer Nature B.V |
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| Abstract | Aims/hypothesis
The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.
Methods
Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (
n
= 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA
1c
.
Results
HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA
1c
at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.
Conclusions/interpretation
The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies.
Graphical abstract |
|---|---|
| AbstractList | Aims/hypothesis
The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.
Methods
Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (
n
= 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA
1c
.
Results
HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA
1c
at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.
Conclusions/interpretation
The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies.
Graphical abstract The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.AIMS/HYPOTHESISThe prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c.METHODSTwo follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c.HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.RESULTSHSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies.CONCLUSIONS/INTERPRETATIONThe associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies. Aims/hypothesisThe prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.MethodsTwo follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c.ResultsHSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders.Conclusions/interpretationThe associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies. |
| Author | Marc Chadeau-Hyam Tim Woelfle Tim Waterboer Barbara Thorand Annette Peters Jochen Seissler Birgit Linkohr |
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| Keywords | Herpes simplex virus 2 (HSV2) Epstein–Barr virus (EBV) HbA Herpes simplex virus 1 (HSV1) Varicella-zoster virus (VZV) Human herpes virus 6 (HHV6) Prediabetes Cytomegalovirus (CMV) Human herpes virus 7 (HHV7) Incidence |
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The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are... Aims/hypothesisThe prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are... The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for... |
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| SubjectTerms | 1103 Clinical Sciences 1114 Paediatrics and Reproductive Medicine 1117 Public Health and Health Services ASSOCIATION CYTOMEGALOVIRUS Cytomegalovirus (CMV) Cytomegalovirus (cmv) ; Epstein–barr Virus (ebv) ; Hba1c ; Herpes Simplex Virus 1 (hsv1) ; Herpes Simplex Virus 2 (hsv2) ; Human Herpes Virus 6 (hhv6) ; Human Herpes Virus 7 (hhv7) ; Incidence ; Prediabetes ; Varicella-zoster Virus (vzv) Cytomegalovirus Infections Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 DIABETES-MELLITUS Endocrinology & Metabolism Epstein-Barr virus Epstein-Barr virus (EBV) Epstein-Barr Virus Infections Glucose Glucose metabolism Glucose tolerance HbA(1c) HbA1c Hemoglobin Herpes simplex Herpes simplex virus 1 (HSV1) Herpes simplex virus 2 (HSV2) Herpes viruses Herpesviridae Herpesviridae Infections Herpesvirus 4 Herpesvirus 4, Human Human Human herpes virus 6 (HHV6) Human herpes virus 7 (HHV7) Human Physiology Humans Immunological tolerance Incidence INFECTIONS Insulin Insulin resistance Internal Medicine Life Sciences & Biomedicine Medicine Medicine & Public Health Metabolic Diseases Physical activity Prediabetes Regression analysis RISK Science & Technology Simplexvirus Type 2 Varicella Varicella-zoster virus (VZV) Viral infections Viruses |
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| Title | Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort |
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