Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort

Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role...

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Published in:Diabetologia Vol. 65; no. 8; pp. 1328 - 1338
Main Authors: Woelfle, Tim, Linkohr, Birgit, Waterboer, Tim, Thorand, Barbara, Seissler, Jochen, Chadeau-Hyam, Marc, Peters, Annette
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Science and Business Media LLC 01.08.2022
Springer Berlin Heidelberg
Springer Nature B.V
Subjects:
1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
1117 Public Health and Health Services
ASSOCIATION
CYTOMEGALOVIRUS
Cytomegalovirus (CMV)
Cytomegalovirus (cmv) ; Epstein–barr Virus (ebv) ; Hba1c ; Herpes Simplex Virus 1 (hsv1) ; Herpes Simplex Virus 2 (hsv2) ; Human Herpes Virus 6 (hhv6) ; Human Herpes Virus 7 (hhv7) ; Incidence ; Prediabetes ; Varicella-zoster Virus (vzv)
Cytomegalovirus Infections
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
DIABETES-MELLITUS
Endocrinology & Metabolism
Epstein-Barr virus
Epstein-Barr virus (EBV)
Epstein-Barr Virus Infections
Glucose
Glucose metabolism
Glucose tolerance
HbA(1c)
HbA1c
Hemoglobin
Herpes simplex
Herpes simplex virus 1 (HSV1)
Herpes simplex virus 2 (HSV2)
Herpes viruses
Herpesviridae
Herpesviridae Infections
Herpesvirus 4
Herpesvirus 4, Human
Human
Human herpes virus 6 (HHV6)
Human herpes virus 7 (HHV7)
Human Physiology
Humans
Immunological tolerance
Incidence
INFECTIONS
Insulin
Insulin resistance
Internal Medicine
Life Sciences & Biomedicine
Medicine
Medicine & Public Health
Metabolic Diseases
Physical activity
Prediabetes
Regression analysis
RISK
Science & Technology
Simplexvirus
Type 2
Varicella
Varicella-zoster virus (VZV)
Viral infections
Viruses
Herpes simplex virus 2 (HSV2)
Epstein–Barr virus (EBV)
HbA
Herpes simplex virus 1 (HSV1)
Varicella-zoster virus (VZV)
Human herpes virus 6 (HHV6)
Prediabetes
Cytomegalovirus (CMV)
Human herpes virus 7 (HHV7)
Incidence
ISSN:0012-186X, 1432-0428, 1432-0428
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Summary:Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology. Methods Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes ( n  = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA 1c . Results HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA 1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders. Conclusions/interpretation The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies. Graphical abstract
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ISSN:0012-186X
1432-0428
1432-0428
DOI:10.1007/s00125-022-05704-7